ReviewPharmacological reports : PR2023
Estrogen fluctuations during the menopausal transition are a risk factor for depressive disorders.
Review in Pharmacological reports : PR, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Effects of different physical activity interventions on depressive symptoms in menopausal women: a systematic review and network meta-analysis.BMC public health · 2025Pooled it
- Lifespan exposure to hormone therapies and structural brain morphometry in older women.NeuroImage · 2026Trial
- Unraveling the Mechanistic Insights ofNutrients · 2026Review
- Clinical evidence on integrated Chinese-Western medicine for perimenopausal syndrome.Integrative medicine research · 2026Article
- Prevalence of anxiety and depression among in-patient and out-patient asthmatic patients in Jordan: A cross-sectional study.Medicine · 2026Article
- Psychedelics and women's mental health: the effects of female sex hormones on psychedelics' efficacy and tolerability.Molecular psychiatry · 2026Review
- Nutritional Interventions for Perimenopausal Anxiety and Depression Targeting Tryptophan and GABA Pathways: A Narrative Review.Nutrients · 2026Review
- Impact of Menopause and Clinical Considerations in Patients With Inflammatory Bowel Disease.Gastroenterology & hepatology · 2026Article
- The Combination ofNutrients · 2026Article
- Study of cognitive functions and heart rate variability in reproductive-age group and post-menopausal women.Indian journal of psychiatry · 2026Article
- Disrupted Estrogen Homeostasis Drives Female-Specific Depressive-Like and Anxiety-Like Behaviors via Convergent ERα Downregulation in the Ventral Hippocampus.International journal of biological sciences · 2026Article
- Association between changes in estradiol, serotonin, and BDNF and antidepressant response in perimenopausal depression: a retrospective cohort study comparing integrated TCM-acupuncture with SSRIs.Frontiers in psychiatry · 2026Article
- Depressive symptoms and cognitive impairment among rural Chinese older women: anxiety and poor sleep as sequential correlates-A cross-sectional analysis.Frontiers in public health · 2026Article
- Research advances on estrogen deficiency leading to depression.Translational neuroscience · 2026Review
- Mitochondrial dysfunction in perimenopausal mood disorders: From hormonal shifts to neuroenergetic failure (Review).International journal of molecular medicine · 2025Review
- Efficacy of Gut Microbiome-Targeted Interventions on Mental Health Symptoms in Women Across Key Hormonal Life Stages: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Healthcare (Basel, Switzerland) · 2025Review
- Observational
- Agmatine Mitigates Diabetes-Related Memory Loss in Female Mice by Targeting IAntioxidants (Basel, Switzerland) · 2025Article
- Inhibition of Semaphorin 3A in Hippocampus Alleviates Postpartum Depression-Like Behaviors in Mice.Molecular neurobiology · 2025Article
- Network Pharmacology-Guided Evaluation of Ginger and Cornelian Cherry Extracts Against Depression and Metabolic Dysfunction in Estrogen-Deficient Chronic Stressed Rats.International journal of molecular sciences · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Women are significantly more likely to develop depression than men. Fluctuations in the ovarian estrogen hormone levels are closely linked with women's well-being. This narrative review discusses the available knowledge on the role of estrogen in modulating brain function and the correlation between changes in estrogen levels and the development of depression. Equally discussed are the possible mechanisms underlying these effects, including the role of estrogen in modulating brain-derived neurotrophic factor activity, serotonin neurotransmission, as well as the induction of inflammatory response and changes in metabolic activity, are discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.