Evidence map›Paper›PMID 36639535›Full record

ArticleEuropean journal of pediatrics2023

Postoperative coagulopathy among otherwise healthy pediatric patients undergoing open craniosynostosis repair: a retrospective study.

Shiri Zarour, Shlomi Constantini, Jonathan Roth, Shirley Friedman, Ilya Kirgner, Barak Cohen, Margaret Ekstein

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in European journal of pediatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07080528 (Measuring of the Duration of Action of Different Doses of Rocuronium-induced Neuromuscular Block in Infants During Surgical Treatment of Craniosynostosis - a Prospective, Case-controlled Study), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07080528 phase4enrolling by invitationnot on this mapstarted 2024, after this paper: background citation

Measuring of the Duration of Action of Different Doses of Rocuronium-induced Neuromuscular Block in Infants During Surgical Treatment of Craniosynostosis - a Prospective, Case-controlled Study

TypeinterventionalSponsorTamas Vegh, MDRan2024 to 2025Enrolled20ConditionsNeuromuscular Blocking Agents, Residual Neuromuscular Block, Neuromuscular Blockade MonitoringArmsSevofluorane, Propofol
3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Shiri ZarourDivision of Anesthesia, Intensive Care, and Pain Management, Tel Aviv Medical Center, Tel Aviv University, Tel Aviv, Israel.
Shlomi ConstantiniDepartment of Pediatric Neurosurgery, Dana Dwek Children's Hospital, Tel Aviv Medical Center, Tel Aviv University, Tel Aviv, Israel.
Jonathan RothDepartment of Pediatric Neurosurgery, Dana Dwek Children's Hospital, Tel Aviv Medical Center, Tel Aviv University, Tel Aviv, Israel.
Shirley FriedmanDepartment of Pediatrics, Pediatric Intensive Care Unit, Dana Dwek Children's Hospital, Tel Aviv Medical Center, Tel Aviv University, Tel Aviv, Israel.
Ilya KirgnerDepartment of Haematology, Director Blood Bank and Apheresis Unit, Tel Aviv Medical Center, Tel Aviv University, Tel Aviv, Israel.
Barak CohenDivision of Anesthesia, Intensive Care, and Pain Management, Tel Aviv Medical Center, Tel Aviv University, Tel Aviv, Israel.
Margaret EksteinDivision of Anesthesia, Intensive Care, and Pain Management, Tel Aviv Medical Center, Tel Aviv University, Tel Aviv, Israel. margaretekstein420@gmail.com.ORCID http://orcid.org/0000-0001-5008-8774
Tel Aviv University · ILCleveland Clinic · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Significant blood loss and resultant transfusion may lead to coagulopathy. The need for routine transfusion of non-RBC blood products in healthy pediatric patients suffering significant, yet controlled, intra-operative blood loss is controversial. Open craniosynostosis surgery is often associated with significant intra-operative blood loss and transfusion, and routinely preformed on otherwise healthy pediatric patients. Therefore, we found it as a useful model for our study, which aimed to assess the need for routine transfusion of non-RBC blood products in healthy pediatric patients suffering significant intra-operative blood loss. We conducted a retrospective cohort study of otherwise healthy pediatric patients, undergoing open craniosynostosis surgery and transfused solely with packed red blood cells (pRBCs) in a single large-volume tertiary surgical center, between January 2010 and December 2021. Among 457 eligible patients, 34 (7.4%) developed significant postoperative coagulopathy. Median [IQR] intra-operative pRBC transfusion volume was 17.4 ml kg

Indexed as

Blood Coagulation DisordersCraniosynostosesErythrocyte TransfusionBlood Loss, SurgicalBlood TransfusionChildHumansIncidenceIsraelPostoperative ComplicationsRetrospective StudiesCoagulopathyIntra-operative hemorrhagePediatricsTransfusion

Identifiers

PMID36639535
OpenAlexW4316020590

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.