Evidence map›Paper›PMID 36639377›Full record

ArticleNature communications2023

Discovery and biosynthesis of karnamicins as angiotensin converting enzyme inhibitors.

Zhiyin Yu, Jian-Ping Huang, Jing Yang, Chongxi Liu, Yijun Yan, Li Wang, Junwei Zhao, Yin Chen, Wensheng Xiang, Sheng-Xiong Huang

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Zhiyin Yu *State Key Laboratory of Southwestern Chinese Medicine Resources, Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, 611137, Chengdu, China.ORCID 0000-0001-8048-302X
Jian-Ping Huang *State Key Laboratory of Southwestern Chinese Medicine Resources, Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, 611137, Chengdu, China.ORCID 0000-0003-1828-0517
Jing Yang *State Key Laboratory of Phytochemistry and Plant Resources in West China, and CAS Center for Excellence in Molecular Plant Sciences, Kunming Institute of Botany, Chinese Academy of Sciences, 650201, Kunming, China.
Chongxi LiuHeilongjiang Provincial Key Laboratory of Agricultural Microbiology, Northeast Agricultural University, 150030, Harbin, China.
Yijun YanState Key Laboratory of Phytochemistry and Plant Resources in West China, and CAS Center for Excellence in Molecular Plant Sciences, Kunming Institute of Botany, Chinese Academy of Sciences, 650201, Kunming, China.ORCID 0000-0001-7727-8084
Li WangState Key Laboratory of Southwestern Chinese Medicine Resources, Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, 611137, Chengdu, China.ORCID 0000-0002-7004-4725
Junwei ZhaoHeilongjiang Provincial Key Laboratory of Agricultural Microbiology, Northeast Agricultural University, 150030, Harbin, China.
Yin ChenState Key Laboratory of Phytochemistry and Plant Resources in West China, and CAS Center for Excellence in Molecular Plant Sciences, Kunming Institute of Botany, Chinese Academy of Sciences, 650201, Kunming, China.
Wensheng XiangHeilongjiang Provincial Key Laboratory of Agricultural Microbiology, Northeast Agricultural University, 150030, Harbin, China. xiangwensheng@neau.edu.cn.ORCID 0000-0002-1826-5985
Sheng-Xiong HuangState Key Laboratory of Southwestern Chinese Medicine Resources, Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, 611137, Chengdu, China. sxhuang@mail.kib.ac.cn.ORCID 0000-0002-3616-8556
Kunming Institute of Botany · CNNortheast Agricultural University · CNChengdu University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Angiotensin-converting enzyme inhibitors are widely used for treatment of hypertension and related diseases. Here, six karnamicins E

Indexed as

Angiotensin-Converting Enzyme InhibitorsAntihypertensive AgentsMixed Function OxygenasesMolecular Docking SimulationPyridinesThiazolesAngiotensin-Converting Enzyme InhibitorsAntihypertensive AgentskarnamicinMixed Function OxygenasesPyridinesThiazoles

Identifiers

PMID36639377
PMCPMC9838390
OpenAlexW4316037186

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.