Evidence map›Paper›PMID 36639287›Full record

ArticleThe Journal of thoracic and cardiovascular surgery2024

Distal aortic progression following acute type A aortic dissection repair among patients with bicuspid and tricuspid aortic valves.

Marc Titsworth, Nathan J Graham, Felix Orelaru, Rana-Armaghan Ahmad, Xiaoting Wu, Karen M Kim, Shinichi Fukuhara, Himanshu Patel, G Michael Deeb, Bo Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of thoracic and cardiovascular surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Marc TitsworthDepartment of Cardiac Surgery, Michigan Medicine, Ann Arbor, Mich.
Nathan J GrahamUniversity of Michigan Medical School, Ann Arbor, Mich.
Felix OrelaruDepartment of General Surgery, St Joseph Mercy, Ann Arbor, Mich.
Rana-Armaghan AhmadDepartment of Cardiac Surgery, Michigan Medicine, Ann Arbor, Mich.
Xiaoting WuDepartment of Cardiac Surgery, Michigan Medicine, Ann Arbor, Mich.
Karen M KimDepartment of Cardiac Surgery, Michigan Medicine, Ann Arbor, Mich.
Shinichi FukuharaDepartment of Cardiac Surgery, Michigan Medicine, Ann Arbor, Mich.
Himanshu PatelDepartment of Cardiac Surgery, Michigan Medicine, Ann Arbor, Mich.
G Michael DeebDepartment of Cardiac Surgery, Michigan Medicine, Ann Arbor, Mich.
Bo YangDepartment of Cardiac Surgery, Michigan Medicine, Ann Arbor, Mich. Electronic address: boya@med.umich.edu.

Funding

Therapeutic Insights into Loeys-Dietz Syndrome using Humanized ModelsR01HL151776 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Bo Yang · 2020 to 2026
$4.2M
Define the mechanisms of aortopathy in bicuspid aortic valve patientsR01HL141891 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI YANG, BO · 2018 to 2022
$3.5M
Effect of mutations in the TGF-beta pathway genes on smooth muscle cell differentiation using patient derived iPSCs.K08HL130614 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI YANG, BO · 2016 to 2020
$848k
NHLBI NIH HHS K08 HL130614NHLBI NIH HHS R01 HL141891NHLBI NIH HHS R01 HL151776
6 · The paper itself

Abstract

objectiveThe study objective was to analyze long-term growth and outcomes of the distal aorta after open acute type A aortic dissection repair in patients with bicuspid aortic valves or tricuspid aortic valves without connective tissue disease.

methodsFrom 1996 to 2021, 60 patients with bicuspid aortic valves and 655 patients with tricuspid aortic valves without connective tissue disease underwent open repair for acute type A aortic dissection. Data were collected from the local Society of Thoracic Surgeons database, medical record review, surveys, and the National Death Index and Michigan Death Index (December 12, 2021).

resultsCompared with the tricuspid aortic valve group, the bicuspid aortic valve group was significantly younger, had more severe aortic insufficiency (33% vs 22%, P = .05), and had less hypertension (67% vs 78%, P = .05). Intraoperatively, patients with bicuspid aortic valves received more aortic root replacements (70% vs 26%, P < .001), less zone 2 aortic arch replacement (8.3% vs 20%, P = .03), and longer median cardiopulmonary bypass (233 vs 214 minutes, P = .05) and aortic crossclamp (184 vs 141 minutes, P < .001) times. The average annual aortic arch growth rate (0.23 mm/year vs 0.39 mm/year, P = .52) and descending aorta growth rate (0.61 mm/year vs 0.79 mm/year, P = .39) were similar between the bicuspid aortic valve and tricuspid aortic valve groups. The bicuspid aortic valve group had lower annual abdominal aorta growth (0.51 mm/year vs 0.68 mm/year, P = .03). The cumulative incidence of reoperation for the distal aorta (9.7% vs 16.0%, P = .77) was similar between the bicuspid aortic valve and tricuspid aortic valve groups. The 10-year survival was higher in the bicuspid aortic valve group (75.4% vs 66.0%, P = .03).

conclusionsPatients with bicuspid aortic valves could be treated similarly as patients with tricuspid aortic valves without connective tissue disease in the setting of open acute type A aortic dissection repair.

Indexed as

Aortic DissectionAortic ValveBicuspid Aortic Valve DiseaseAcute DiseaseAdultAgedAortic AneurysmAortic Aneurysm, ThoracicBlood Vessel Prosthesis ImplantationDisease ProgressionFemaleHeart Valve DiseasesHumansMaleMiddle AgedRetrospective Studiesacute type A aortic dissectionbicuspid aortic valvetricuspid aortic valve

Identifiers

PMID36639287
PMCPMC10282108

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.