Evidence map›Paper›PMID 36638956›Full record

ArticleJournal of cardiac failure2023

Multiple Prior Live Births Are Associated With Cardiac Remodeling and Heart Failure Risk in Women.

Amy A Sarma, Samantha M Paniagua, Emily S Lau, Dongyu Wang, Elizabeth E Liu, Martin G Larson, Naomi M Hamburg, Gary F Mitchell, Jorge Kizer, Bruce M Psaty and 13 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiac failure, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
4.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors at 12 institutions in 2 countries.

Amy A SarmaCardiology Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Samantha M PaniaguaCardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.
Emily S LauCardiology Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.
Dongyu WangCardioVascular Institute and Division of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Elizabeth E LiuCardioVascular Institute and Division of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Martin G LarsonNational Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.
Naomi M HamburgDepartment of Medicine, Sections of Cardiology and Vascular Medicine, Boston University School of Medicine, Boston, MA, USA.
Gary F MitchellDepartment of Research, Cardiovascular Engineering, Norwood, MA, USA.
Jorge KizerAlbert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA.
Bruce M PsatyCardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Services, University of Washington, Seattle, WA, USA; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.
Norrina B AllenDepartment of Epidemiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
A Titia LelyDepartment of Obstetrics and Gynaecology, University Medical Center Groningen, University of Groningen, The Netherlands.
Ronald T GansevoortDivision of Nephrology, Department of Medicine, University Medical Center Groningen, The Netherlands.
Emily RosenbergDivision of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Boston, MA, USA.
Kenneth MukamalBeth Israel Deaconess Medical Center, Boston, MA, USA.
Emelia J BenjaminNational Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA; Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA; Cardiovascular Medicine Section, Department of Medicine and Section of Preventive Medicine and Epidemiology, Boston University School of Medicine, Boston, MA, USA.
Ramachandran S VasanNational Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA; Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA; Cardiovascular Medicine Section, Department of Medicine and Section of Preventive Medicine and Epidemiology, Boston University School of Medicine, Boston, MA, USA; Boston University Center for Computing and Data Sciences, Boston, MA, USA.
Susan ChengSmidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Daniel LevyNational Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.
Rudolf A DE BoerDepartment of Cardiology, University of Groningen, University Medical Center Groningen, The Netherlands.
John S GottdienerUniversity of Maryland, Baltimore, MD, USA.
Sanjiv J ShahDivision of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Jennifer E HoCardioVascular Institute and Division of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA. Electronic address: jho@bidmc.harvard.edu.
Beth Israel Deaconess Medical Center · USBoston University · USMassachusetts General Hospital · USUniversity Medical Center Groningen · NLNational Heart Lung and Blood Institute · USNorthwestern University · USAlbert Einstein College of Medicine · USBrigham and Women's Hospital · USCedars-Sinai Medical Center · USKaiser Permanente Washington Health Research Institute · USNorwood Hospital · USUniversity of Maryland, Baltimore · US

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Framingham Project/LevyZIAHL006001 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEVY, DANIEL · 2009 to 2025
$51.1M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
FRAMINGHAM HEART STUDY - YEAR 5 EXAM75N92019D00031 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · 2019 to 2024
$29.8M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVALR01HL092577 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BENJAMIN, EMELIA J., ELLINOR, PATRICK THOMAS · 2009 to 2025
$20.6M
ConProject-006U54HL120163 · NHLBI · AMERICAN HEART ASSOCIATION · PI BHATNAGAR, ARUNI, ROBERTSON, ROSE MARIE · 2018 to 2022
$18.8M
Exceptional Survival: Trajectories to Functional Aging (CHS All Stars)R01AG023629 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEWMAN, ANNE B. · 2004 to 2016
$9.5M
The Microvascular Aging and Eicosanoids - Women's Evaluation of Systemic Aging Tenacity (MAE-WEST) ("You are never too old to become younger!") Specialized Center for Research Excellence (SCORE)U54AG065141 · NIA · CEDARS-SINAI MEDICAL CENTER · PI CHENG, SUSAN · 2020 to 2024
$8.7M
CHS research resources for the cardiovascular health of older adultsU01HL130114 · NHLBI · UNIVERSITY OF WASHINGTON · PI BURKE, GREGORY L, KRONMAL, RICHARD A · 2016 to 2019
$6.6M
NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NCATS NIH HHS UL1 TR001881NHLBI NIH HHS 75N92019D00031NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001INHLBI NIH HHS HHSN268201500003CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS K23 HL159243NHLBI NIH HHS K24 HL153669NHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS R01 HL060040NHLBI NIH HHS R01 HL070100NHLBI NIH HHS R01 HL071039NHLBI NIH HHS R01 HL076784NHLBI NIH HHS R01 HL077447NHLBI NIH HHS R01 HL080124NHLBI NIH HHS R01 HL092577NHLBI NIH HHS R01 HL107385NHLBI NIH HHS R01 HL107577NHLBI NIH HHS R01 HL126136NHLBI NIH HHS R01 HL127028NHLBI NIH HHS R01 HL131532NHLBI NIH HHS R01 HL134168NHLBI NIH HHS R01 HL134893NHLBI NIH HHS R01 HL140224NHLBI NIH HHS R01 HL140731NHLBI NIH HHS R01 HL141434NHLBI NIH HHS R01 HL142983NHLBI NIH HHS R01 HL143227NHLBI NIH HHS R01 HL149423NHLBI NIH HHS R01 HL160003NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL130114NHLBI NIH HHS U54 HL120163NIA NIH HHS R01 AG023629NIA NIH HHS R01 AG028321NIA NIH HHS R01 AG066010NIA NIH HHS U54 AG065141NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK083538
6 · The paper itself

Abstract

objectiveGreater parity has been associated with cardiovascular disease risk. We sought to find whether the effects on cardiac remodeling and heart failure risk are clear.

methodsWe examined the association of number of live births with echocardiographic measures of cardiac structure and function in participants of the Framingham Heart Study (FHS) using multivariable linear regression. We next examined the association of parity with incident heart failure with preserved (HFpEF) or reduced (HFrEF) ejection fraction using a Fine-Gray subdistribution hazards model in a pooled analysis of n = 12,635 participants in the FHS, the Cardiovascular Health Study, the Multi-Ethnic Study of Atherosclerosis, and Prevention of Renal and Vascular Endstage Disease. Secondary analyses included major cardiovascular disease, myocardia infarction and stroke.

resultsAmong n = 3931 FHS participants (mean age 48 ± 13 years), higher numbers of live births were associated with worse left ventricular fractional shortening (multivariable β -1.11 (0.31); P = 0.0005 in ≥ 5 live births vs nulliparous women) and worse cardiac mechanics, including global circumferential strain and longitudinal and radial dyssynchrony (P < 0.01 for all comparing ≥ 5 live births vs nulliparity). When examining HF subtypes, women with ≥ 5 live births were at higher risk of developing future HFrEF compared with nulliparous women (HR 1.93, 95% CI 1.19-3.12; P = 0.008); by contrast, a lower risk of HFpEF was observed (HR 0.58, 95% CI 0.37-0.91; P = 0.02).

conclusionsGreater numbers of live births are associated with worse cardiac structure and function. There was no association with overall HF, but a higher number of live births was associated with greater risk for incident HFrEF.

Indexed as

Heart FailureMyocardial InfarctionAdultFemaleHumansLive BirthMiddle AgedPregnancyPrognosisRisk FactorsStroke VolumeVentricular Function, LeftVentricular Remodelingechocardiographyheart failurePregnancy

Identifiers

PMID36638956
PMCPMC10333450
OpenAlexW4315471299

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.