Evidence map›Paper›PMID 36638317›Full record

ArticleBiochemistry2023

Biosynthesis of Isonitrile Lipopeptide Metallophores from Pathogenic Mycobacteria.

Antonio Del Rio Flores, Maanasa Narayanamoorthy, Wenlong Cai, Rui Zhai, Siyue Yang, Yuanbo Shen, Kaushik Seshadri, Kyle De Matias, Zhaoqiang Xue, Wenjun Zhang

Open access · greenAbstract read
In one paragraph

Article in Biochemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Kupyaphores─Self-Assembling Diisocyanolipopeptide ZnJournal of the American Chemical Society · 2025
    Article
  3. Article
  4. Article
  5. Biosynthesis of isonitrile lipopeptides.Current opinion in chemical biology · 2024
    Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Antonio Del Rio FloresDepartment of Chemical and Biomolecular Engineering, University of California, Berkeley, California 94720, United States.ORCID 0000-0001-5893-3557
Maanasa NarayanamoorthyDepartment of Chemistry, University of California, Berkeley, California 94720, United States.ORCID 0000-0002-7418-2607
Wenlong CaiDepartment of Chemical and Biomolecular Engineering, University of California, Berkeley, California 94720, United States.
Rui ZhaiDepartment of Chemical and Biomolecular Engineering, University of California, Berkeley, California 94720, United States.ORCID 0000-0001-5032-9689
Siyue YangDepartment of Chemistry, University of California, Berkeley, California 94720, United States.ORCID 0000-0002-0516-4624
Yuanbo ShenDepartment of Chemistry, University of California, Berkeley, California 94720, United States.ORCID 0000-0001-9464-7320
Kaushik SeshadriDepartment of Chemical and Biomolecular Engineering, University of California, Berkeley, California 94720, United States.ORCID 0000-0003-3436-4585
Kyle De MatiasDepartment of Chemical and Biomolecular Engineering, University of California, Berkeley, California 94720, United States.ORCID 0000-0001-9072-9599
Zhaoqiang XueDepartment of Chemical and Biomolecular Engineering, University of California, Berkeley, California 94720, United States.
Wenjun ZhangDepartment of Chemical and Biomolecular Engineering, University of California, Berkeley, California 94720, United States.ORCID 0000-0001-9348-972X
University of California, Berkeley · US

Funding

Biosynthesis of unusual bio-orthogonal functionalities in natural productsR01GM136758 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI ZHANG, WENJUN · 2020 to 2023
$1.5M
NIGMS NIH HHS R01 GM136758
6 · The paper itself

Abstract

Isonitrile lipopeptides (INLPs) are known to be related to the virulence of pathogenic mycobacteria by mediating metal transport, but their biosynthesis remains obscure. In this work, we use in vitro biochemical assays, site-directed mutagenesis, chemical synthesis, and spectroscopy techniques to scrutinize the activity of core enzymes required for INLP biosynthesis in mycobacteria. Compared to environmental

Indexed as

LipopeptidesMycobacterium tuberculosisMetalsMutagenesis, Site-DirectedLipopeptidesMetals

Identifiers

PMID36638317
PMCPMC9905339
OpenAlexW4316022293

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.