Evidence map›Paper›PMID 36638276›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2023

Thiolated Mesoporous Silica Nanoparticles as an Immunoadjuvant to Enhance Efficacy of Intravesical Chemotherapy for Bladder Cancer.

Cheng-Che Chen, Yu-Chen Fa, Yen-Yu Kuo, Yi-Chun Liu, Chih-Yu Lin, Xin-Hui Wang, Yu-Huan Lu, Yu-Han Chiang, Chia-Min Yang, Li-Chen Wu and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Cheng-Che ChenBioAnalytical Chemistry and Nanobiomedicine Laboratory, Department of Biochemical Science and Technology, National Taiwan University, 10617, Taipei, Taiwan.ORCID 0000-0002-6539-0156
Yu-Chen FaBioAnalytical Chemistry and Nanobiomedicine Laboratory, Department of Biochemical Science and Technology, National Taiwan University, 10617, Taipei, Taiwan.ORCID 0000-0002-6514-764X
Yen-Yu KuoDepartment of Chemistry, National Tsing Hua University, 300044, Hsinchu, Taiwan.
Yi-Chun LiuBioAnalytical Chemistry and Nanobiomedicine Laboratory, Department of Biochemical Science and Technology, National Taiwan University, 10617, Taipei, Taiwan.
Chih-Yu LinDepartment of Chemistry, National Tsing Hua University, 300044, Hsinchu, Taiwan.
Xin-Hui WangInstrumentation Center, National Taiwan University, 10617, Taipei, Taiwan.ORCID 0000-0001-8697-4209
Yu-Huan LuDepartment of Chemistry, National Tsing Hua University, 300044, Hsinchu, Taiwan.
Yu-Han ChiangDepartment of Chemistry, National Taiwan University, 10617, Taipei, Taiwan.
Chia-Min YangDepartment of Chemistry, National Tsing Hua University, 300044, Hsinchu, Taiwan.ORCID 0000-0001-9990-4779
Li-Chen WuDepartment of Applied Chemistry, National Chi Nan University, Puli, Nantou, 54561, Taiwan.ORCID 0000-0001-9908-1215
Ja-An Annie HoBioAnalytical Chemistry and Nanobiomedicine Laboratory, Department of Biochemical Science and Technology, National Taiwan University, 10617, Taipei, Taiwan.ORCID 0000-0001-6684-1118
National Taipei University of Technology · TWNational Tsing Hua University · TWNational Taiwan University · TWNational Chi Nan University · TW

Funding

Instrumentation Center of National Taiwan University MOST110-2731-M-002-001Instrumentation Center of National Tsing Hua University for the thermogravimetric analysis MOST110-2731-M-007-001Ministry of Education (MOE) of Taiwan : Higher Education Sprout ProjectMinistry of Science and Technology (MOST) of Taiwan 106-2113-M-002-014-MY3Ministry of Science and Technology (MOST) of Taiwan 109-2113-M-007-018-MY3Ministry of Science and Technology (MOST) of Taiwan MOST102-2628-M-002-004-MY4Ministry of Science and Technology (MOST) of Taiwan MOST107-2113-M-260-002-MY2Ministry of Science and Technology (MOST) of Taiwan MOST111-2634-F-007-007Taichung Veterans General Hospital
6 · The paper itself

Abstract

The characteristics of global prevalence and high recurrence of bladder cancer has led numerous efforts to develop new treatments. The spontaneous voiding and degradation of the chemodrug hamper the efficacy and effectiveness of intravesical chemotherapy following tumor resection. Herein, the externally thiolated hollow mesoporous silica nanoparticles (MSN-SH(E)) is fabricated to serve as a platform for improved bladder intravesical therapy. Enhanced mucoadhesive effect of the thiolated nanovector is confirmed with porcine bladder. The permeation-enhancing effect is also verified, and a fragmented distribution pattern of a tight junction protein, claudin-4, indicates the opening of tight junction. Moreover, MSN-SH(E)-associated reprogramming of M2 macrophages to M1-like phenotype is observed in vitro. The antitumor activity of the mitomycin C (MMC)-loaded nanovector (MMC@MSN-SH(E)) is more effective than that of MMC alone in both in vitro and in vivo. In addition, IHC staining is used to analyze IFN-γ, TGF-β1, and TNF-α. These observations substantiated the significance of MMC@MSN-SH(E) in promoting anticancer activity, holding the great potential for being used in intravesical therapy for non-muscle invasive bladder cancer (NMIBC) due to its mucoadhesivity, enhanced permeation, immunomodulation, and prolonged and very efficient drug exposure.

Indexed as

NanoparticlesUrinary Bladder NeoplasmsAdjuvants, ImmunologicAnimalsAntibiotics, AntineoplasticMitomycinSilicon DioxideSwineAdjuvants, ImmunologicAntibiotics, AntineoplasticMitomycinSilicon Dioxidebladder cancerintravesical therapymesoporous silica nanoparticlemitomycin Cthiol modification

Identifiers

PMID36638276
PMCPMC9982584
OpenAlexW4316013958

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.