ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2023
Mimicking the Biological Sense of Taste In Vitro Using a Taste Organoids-on-a-Chip System.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Real-time sensing-integrated organoid-on-a-chip platforms: Technological progress and emerging biomedical applications.Bioactive materials · 2026Review
- Organoids for disease modeling and treatment: state-of-the-art.Experimental hematology & oncology · 2026Review
- A Taste Bud Organoid-Based Biosensor with a 3-Dimensional Microelectrode Array for Evaluating Caffeine's Impacts on Taste Sensing.BME frontiers · 2026Article
- Functional material probes and advanced technologies in organ-on-a-chip characterization.Theranostics · 2026Review
- Innovative organ-on-a-chip platforms for exploring tumorigenesis and therapy in head and neck cancer.Journal of translational medicine · 2025Review
- Organoid models for chemosensing cell studies.American journal of physiology. Cell physiology · 2025Review
- Long-term culture and morphological maturation of taste organoids enhance taste discrimination in a biomimetic biosensor.Microsystems & nanoengineering · 2025Article
- Biomedical applications of organoids derived from the digestive system.Frontiers in cell and developmental biology · 2025Review
- Biomimetic Wearable Sensors: Emerging Combination of Intelligence and Electronics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Longitudinal imaging of the taste bud in vivo with two-photon laser scanning microscopy.PloS one · 2024Article
- Recent Methods for Modifying Mechanical Properties of Tissue-Engineered Scaffolds for Clinical Applications.Biomimetics (Basel, Switzerland) · 2023Review
- Mimicking the Biological Sense of Taste In Vitro Using a Taste Organoids-on-a-Chip System.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Thanks to the gustatory system, humans can experience the flavors in foods and drinks while avoiding the intake of some harmful substances. Although great advances in the fields of biotechnology, microfluidics, and nanotechnologies have been made in recent years, this astonishing recognition system can hardly be replaced by any artificial sensors designed so far. Here, taste organoids are coupled with an extracellular potential sensor array to form a novel bioelectronic organoid and developed a taste organoids-on-a-chip system (TOS) for highly mimicking the biological sense of taste ex vivo with high stability and repeatability. The taste organoids maintain key taste receptors expression after the third passage and high cell viability during 7 days of on-chip culture. Most importantly, the TOS not only distinguishs sour, sweet, bitter, and salt stimuli with great specificity, but also recognizes varying concentrations of the stimuli through an analytical method based on the extraction of signal features and principal component analysis. It is hoped that this bioelectronic tongue can facilitate studies in food quality controls, disease modelling, and drug screening.
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Registered trials
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