ArticleScience advances2023
Nicotinamide riboside improves muscle mitochondrial biogenesis, satellite cell differentiation, and gut microbiota in a twin study.
Open access · goldAbstract readTwin Study
In one paragraph
Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 5 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed, 5 pooled it
20.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
83 citing papers in PubMed, 5 syntheses or guidelines pooled it, 113 citations in OpenAlex.
- Mechanistic pathways linking gut microbial metabolites, microbial structural products, and host-microbe co-metabolites to mitochondrial function.Gut microbes · 2026Pooled it
- Domain-specific effects of NADFrontiers in nutrition · 2026Pooled it
- The Effect of Nicotinamide Mononucleotide and Riboside on Skeletal Muscle Mass and Function: A Systematic Review and Meta-Analysis.Journal of cachexia, sarcopenia and muscle · 2025Pooled it
- Effects of Nicotinamide Mononucleotide on Glucose and Lipid Metabolism in Adults: A Systematic Review and Meta-analysis of Randomised Controlled Trials.Current diabetes reports · 2024Pooled it
- The effects of NAD+ precursor (nicotinic acid and nicotinamide) supplementation on weight loss and related hormones: a systematic review and meta-regression analysis of randomized controlled trials.Frontiers in nutrition · 2023Pooled it
- NAD+ augmentation by nicotinamide riboside engages SLIT2/ROBO1 signaling to attenuate Th17 inflammation in psoriasis.JCI insight · 2026Trial
- Nicotinamide and Pyridoxine Supplementation Enhances Muscle Stem Cell Activity and Muscle Regeneration in Humans: A Randomized Placebo-Controlled Clinical Trial of High Force Eccentric Contraction Recovery in Healthy Young Men.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Trial
- Quizartinib and omacetaxine mepesuccinate combination therapy in FLT3-ITD AML: a phase II trial.Nature communications · 2026Trial
- Effects of NADThe Journal of pharmacology and experimental therapeutics · 2025Trial
- Effect of nicotinamide riboside on airway inflammation in COPD: a randomized, placebo-controlled trial.Nature aging · 2024Trial
- NR-SAFE: a randomized, double-blind safety trial of high dose nicotinamide riboside in Parkinson's disease.Nature communications · 2023Trial
- Randomized crossover clinical trial of coenzyme Q10 and nicotinamide riboside in chronic kidney disease.JCI insight · 2023Trial
- Immunometabolic reprogramming in multiple sclerosis: from pathogenic amplifier to therapeutic target in neuroinflammation and remyelination.Inflammopharmacology · 2026Review
- Nicotinamide riboside enhances adoptive T cell therapy by promoting memory differentiation and metabolic fitness.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Article
- The Divergent Effects of Nicotinamide Riboside and High-Intensity Exercise Training on Skeletal Muscle Epigenetic Aging.Aging cell · 2026Article
- Metabolite-driven remodeling of hepatic lipid metabolism by the plasticizer di-isononyl phthalate.Molecular metabolism · 2026Article
- NAD⁺ biology and supplementation: From mechanisms to clinical perspectives.Molecular biology reports · 2026Review
- Mitochondrial quality control in human ageing and longevity.Nature metabolism · 2026Review
- Nicotinamide riboside prevents mitochondrial dysfunction in nemaline myopathy type 6.Human molecular genetics · 2026Article
- Reactive oxygen species and metabolic checkpoints shape plasmacytoid dendritic cell fate in infection and autoimmunity.Redox biology · 2026Review
23 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
27 authors at 5 institutions in 4 countries.
Helena A K LapattoObesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, FIN-00014 Helsinki, Finland.ORCID 0000-0002-6655-4415
Minna KuuselaResearch Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, FIN-00014 Helsinki, Finland.ORCID 0000-0001-7847-5629
Aino HeikkinenInstitute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.ORCID 0000-0001-5770-6475
Maheswary MuniandyObesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, FIN-00014 Helsinki, Finland.ORCID 0000-0001-7624-7948
Birgitta W van der KolkObesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, FIN-00014 Helsinki, Finland.ORCID 0000-0001-8608-541X
Swetha GopalakrishnanInstitute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.ORCID 0000-0002-4717-4521
Noora PöllänenResearch Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, FIN-00014 Helsinki, Finland.ORCID 0000-0002-3295-1260
Martin SandvikInstitute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.ORCID 0000-0003-2013-4420
Mark S SchmidtDepartment of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.ORCID 0000-0003-4593-4096
Sini HeinonenObesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, FIN-00014 Helsinki, Finland.ORCID 0000-0002-6342-0577
Sina SaariObesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, FIN-00014 Helsinki, Finland.ORCID 0000-0003-4663-022X
Juho KuulaDepartment of Radiology, Medical Imaging Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.ORCID 0000-0002-5793-9196
Antti HakkarainenDepartment of Radiology, Medical Imaging Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.ORCID 0000-0002-7367-2532
Janne TampioSchool of Pharmacy, University of Eastern Finland, Kuopio, Finland.ORCID 0000-0002-7526-0419
Tuure SaarinenObesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, FIN-00014 Helsinki, Finland.ORCID 0000-0002-7508-4849
Marja-Riitta TaskinenResearch Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, FIN-00014 Helsinki, Finland.ORCID 0000-0002-6229-3588
Nina LundbomDepartment of Radiology, Medical Imaging Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.ORCID 0000-0003-3294-8173
Per-Henrik GroopResearch Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, FIN-00014 Helsinki, Finland.ORCID 0000-0003-4055-6954
Marja TiirolaDepartment of Environmental and Biological Sciences, University of Jyväskylä, FI-40014 Jyväskylä, Finland.ORCID 0000-0001-5589-3748
Pekka KatajistoInstitute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.ORCID 0000-0002-3033-4189
Marko LehtonenSchool of Pharmacy, University of Eastern Finland, Kuopio, Finland.ORCID 0000-0002-5611-0466
Charles BrennerDepartment of Diabetes and Cancer Metabolism, City of Hope National Medical Center, Duarte, CA 91010, USA.ORCID 0000-0002-4955-3226
Jaakko KaprioResearch Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, FIN-00014 Helsinki, Finland.ORCID 0000-0002-3716-2455
Satu PekkalaFaculty of Sport and Health Sciences, University of Jyväskylä, FI-40014 Jyväskylä, Finland.ORCID 0000-0003-3107-0813
Miina OllikainenResearch Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, FIN-00014 Helsinki, Finland.ORCID 0000-0003-3661-7400
Kirsi H PietiläinenObesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, FIN-00014 Helsinki, Finland.ORCID 0000-0002-8522-1288
Eija PirinenResearch Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, FIN-00014 Helsinki, Finland.ORCID 0000-0002-9821-2516
University of Helsinki · FIUniversity of Eastern Finland · FIUniversity of Jyväskylä · FICity Of Hope National Medical Center · USUniversity of Iowa · US
Funding
The SIRT1-Gpd1L-NAD+ interactome in regulation of the Neuronal Sodium Channel: Implications for Cognitive Impairment of Alzheimerâs DementiaR01HL147545 · NHLBI · UNIVERSITY OF IOWA · PI BRENNER, CHARLES M, IRANI, KAIKOBAD J. · 2019 to 2022
$2.9MNHLBI NIH HHS R01 HL147545
Abstract
Nicotinamide adenine dinucleotide (NAD
Indexed as
Gastrointestinal MicrobiomeNADAnimalsCell DifferentiationHumansMiceMuscle, SkeletalNiacinamideObesityOrganelle BiogenesisPyridinium CompoundsNADNiacinamidenicotinamide-beta-ribosidePyridinium Compounds
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.