ArticlePerfusion2024
Validation of the slaughterhouse porcine heart model for ex-situ heart perfusion studies.
Article in Perfusion, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 10 citations in OpenAlex.
- Real-time magnetic resonance-guided radiofrequency ablation and lesion evaluation in an magnetic resonance-compatible isolated beating pig heart platform.Heart rhythm O2 · 2025Article
- Innovative balloon-inflatable venous cannula for enhanced cardiopulmonary bypass in minimally invasive cardiac surgery.Interdisciplinary cardiovascular and thoracic surgery · 2025Article
- A Cardioprotective perfusion protocol limits myocardial functional decline during ex situ heart perfusion.JHLT open · 2024Article
- Electrophysiological Markers ofTransplant international : official journal of the European Society for Organ Transplantation · 2024Article
- Transplant international : official journal of the European Society for Organ Transplantation · 2024Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionTo validate slaughterhouse hearts for
methodsAll hearts received modified St Thomas 2 crystalloid cardioplegia prior to 4 hours of cold oxygenated machine perfusion. Hearts were perfused with homemade modified Steen heart solution with a perfusion pressure of 20-25 mmHg to achieve a coronary flow between 100-200 mL/min. Reperfusion and testing was performed for 4 hours on a normothermic, oxygenated diluted whole blood loaded heart model. Survival was defined by a cardiac output above 3 L with a mean aortic pressure above 60 mmHg.
resultsBoth groups showed 100% functional survival, with laboratory hearts displaying superior cardiac function. Both groups showed similar decline in function over time.
conclusionWe conclude that the slaughterhouse heart can be used as an alternative to laboratory hearts and provides a cost-effective method for future
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.