Evidence map›Paper›PMID 36637971›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2023

Increased length-dependent activation of human engineered heart tissue after chronic α

C Rupert, J E López, E Cortez-Toledo, O De la Cruz Cabrera, N C Chesler, P C Simpson, S G Campbell, A J Baker

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

C RupertPropria LLC, Branford, Connecticut, United States.ORCID 0000-0001-7923-8246
J E LópezDivision of Cardiovascular Medicine, Department of Internal Medicine, University of California Davis, Davis, California, United States.
E Cortez-ToledoDivision of Cardiovascular Medicine, Department of Internal Medicine, University of California Davis, Davis, California, United States.
O De la Cruz CabreraKent State University, Kent, Ohio, United States.ORCID 0000-0002-7317-2968
N C CheslerEdwards Lifesciences Foundation Cardiovascular Innovation Research Center, Irvine, California, United States.ORCID 0000-0002-7612-5796
P C SimpsonCardiology Division, Veterans Affairs Medical Center, San Francisco, California, United States.
S G CampbellDepartments of Biomedical Engineering and Cellular and Molecular Physiology, Yale University, New Haven, Connecticut, United States.ORCID 0000-0002-1527-0770
A J BakerCardiology Division, Veterans Affairs Medical Center, San Francisco, California, United States.ORCID 0000-0001-6211-4108
San Francisco VA Medical Center · USUniversity of California, Davis · USKent State University · USUniversity of California, Irvine · USYale University · US

Funding

CATECHOLAMINES AND HYPERTROPHY OF CULTURED HEART CELLSR01HL031113 · NHLBI · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI SIMPSON, PAUL C · 1985 to 2021
$5.7M
Multiscale Mechanobiology of Right Ventricular FailureR01HL154624 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Anthony J. BAKER, DANIEL A BEARD · 2020 to 2026
$4.9M
Acquisition of Covaris E220 and Sciclone G3 systems for high throughput sequencinS10OD010786 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI COMAI, LUCA · 2012 to 2012
$311k
Right Heart Function in Health and Chronic Lung DiseaseI01BX000740 · VA · VETERANS AFFAIRS MED CTR SAN FRANCISCO · PI Anthony J. BAKER · 2011 to 2026
–
BLRD VA I01 BX000740NHLBI NIH HHS R01 HL031113NHLBI NIH HHS R01 HL154624NIH HHS S10 OD010786
6 · The paper itself

Abstract

Chronic stimulation of cardiac α

Indexed as

Heart FailureInduced Pluripotent Stem CellsAdrenergic AgonistsAnimalsHumansMyocardial ContractionMyocytes, CardiacReceptors, AdrenergicReceptors, Adrenergic, alpha-1SwineAdrenergic AgonistsReceptors, AdrenergicReceptors, Adrenergic, alpha-1engineered heart tissueheart failurehumaninduced pluripotent stem cellα1A-adrenergic receptor

Identifiers

PMID36637971
PMCPMC9886349
OpenAlexW4315928656

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.