Evidence map›Paper›PMID 36637968›Full record

ArticleDiabetes care2023

Objective and Subjective Sleep Patterns in Adults With Maturity-Onset Diabetes of the Young (MODY).

Marilyn Arosemena, Maria V Salguero, Rochelle N Naylor, Kristen Wroblewski, Esra Tasali, Louis H Philipson

Open access · greenAbstract read
In one paragraph

Article in Diabetes care, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Marilyn Arosemena1Department of Medicine, The University of Chicago, Chicago, IL.ORCID 0000-0002-8185-4707
Maria V Salguero1Department of Medicine, The University of Chicago, Chicago, IL.
Rochelle N Naylor1Department of Medicine, The University of Chicago, Chicago, IL.
Kristen Wroblewski3Department of Public Health Sciences, The University of Chicago, Chicago, IL.
Esra Tasali1Department of Medicine, The University of Chicago, Chicago, IL.
Louis H Philipson1Department of Medicine, The University of Chicago, Chicago, IL.
University of Chicago · USChicago Department of Public Health · US

Funding

Vanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ALVIN C POWERS · 2012 to 2026
$29.3M
RADIANT Clinic and Data Coordinating CenterU54DK118612 · NIDDK · UNIVERSITY OF CHICAGO · PI Louis H. Philipson · 2018 to 2026
$21.9M
Pilot and Feasibility ProgramP30DK020595 · NIDDK · UNIVERSITY OF CHICAGO · PI Raghavendra G Mirmira · 2013 to 2026
$20.9M
CLINICAL THERAPEUTICST32GM007019 · NIGMS · UNIVERSITY OF CHICAGO · PI Peter Hugh O'Donnell, MARK J RATAIN · 1985 to 2026
$8.7M
Monogenic Diabetes: Next Generation Diagnosis, Treatment and ComplicationsR01DK104942 · NIDDK · UNIVERSITY OF CHICAGO · PI GREELEY, SIRI ATMA W., PHILIPSON, LOUIS H. · 2016 to 2024
$4.7M
Technology-Supported Treatment of Sleep Apnea in PrediabetesR01DK120312 · NIDDK · UNIVERSITY OF CHICAGO · PI TASALI, ESRA · 2019 to 2023
$3.9M
REGUL. OF GENE EXPRESSION IN PROKARYOTES AND EUKARYOTEST32GM007196 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WINSTON, FRED M. · 1985 to 2005
$2.8M
NIDDK NIH HHS P30 DK020593NIDDK NIH HHS P30 DK020595NIDDK NIH HHS R01 DK104942NIDDK NIH HHS R01 DK120312NIDDK NIH HHS U54 DK118612NIGMS NIH HHS T32 GM007019NIGMS NIH HHS T32 GM007196
6 · The paper itself

Abstract

objectiveTo examine sleep patterns in adults with maturity-onset diabetes of the young (MODY). RESEARCH DESIGN AND

methodsAdults with glucokinase (GCK)-MODY and transcription factor (TF)-related MODY (HNF1A, HNF1B, HNF4A) were recruited (n = 24; age 46.0 years, 79% women, BMI 24.7 kg/m2) from The University of Chicago's Monogenic Diabetes Registry. Sleep patterns were assessed by 2-week wrist actigraphy (total 315 nights), one night of a home sleep apnea test, and validated surveys.

resultsOverall, compared with established criteria, 29% of participants had sleep latency ≥15 min, 38% had sleep efficiency ≤85%, 46% had wake after sleep onset >40 min, all indicating poor objective sleep quality. Among all participants, 54% had a sleep duration below the recommended minimum of 7 h, 88% reported poor sleep quality, 58% had obstructive sleep apnea, and 71% reported insomnia. Compared with GCK-MODY, participants with TF-related MODY had poorer objective sleep quality and increased night-to-night variability in sleep patterns.

conclusionsSleep disturbances appear to be common in adults with MODY despite absent traditional risk factors for sleep disorders. Future research investigating the sleep-diabetes relationship is warranted in this population.

Indexed as

Diabetes Mellitus, Type 2SleepSleep Disorders, IntrinsicFemaleGlucokinaseHepatocyte Nuclear Factor 1-alphaHumansMaleMiddle AgedMutationRisk FactorsGlucokinaseHepatocyte Nuclear Factor 1-alpha

Identifiers

PMID36637968
PMCPMC10090264
OpenAlexW4315928390

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.