Evidence map›Paper›PMID 36637792›Full record

ArticleActa neurologica Belgica2023

Temporal lobe atrophy as a potential predictor of functional outcome in older adults with acute ischemic stroke.

Fabrizio Sallustio, Alfredo Paolo Mascolo, Federico Marrama, Federica D'Agostino, Marco Proietti, Laura Greco, Francesca Di Giuliano, Fana Alemseged, Roberto Gandini, Alessandro Martorana and 2 more

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Article in Acta neurologica Belgica, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Fabrizio SallustioComprehensive Stroke Center, Department of Systems Medicine, University of Tor Vergata, Viale Oxford 81, 00133, Rome, Italy. fsall75@gmail.com.
Alfredo Paolo MascoloComprehensive Stroke Center, Department of Systems Medicine, University of Tor Vergata, Viale Oxford 81, 00133, Rome, Italy.ORCID http://orcid.org/0000-0003-0568-7211
Federico MarramaComprehensive Stroke Center, Department of Systems Medicine, University of Tor Vergata, Viale Oxford 81, 00133, Rome, Italy.
Federica D'AgostinoComprehensive Stroke Center, Department of Systems Medicine, University of Tor Vergata, Viale Oxford 81, 00133, Rome, Italy.
Marco ProiettiDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Laura GrecoDiagnostic Neuroradiology Unit, Department of Biomedicine and Prevention, University of Tor Vergata, Rome, Italy.
Francesca Di GiulianoDiagnostic Neuroradiology Unit, Department of Biomedicine and Prevention, University of Tor Vergata, Rome, Italy.
Fana AlemsegedComprehensive Stroke Center, Department of Systems Medicine, University of Tor Vergata, Viale Oxford 81, 00133, Rome, Italy.
Roberto GandiniDiagnostic Neuroradiology Unit, Department of Biomedicine and Prevention, University of Tor Vergata, Rome, Italy.
Alessandro MartoranaComprehensive Stroke Center, Department of Systems Medicine, University of Tor Vergata, Viale Oxford 81, 00133, Rome, Italy.
Marina DiomediComprehensive Stroke Center, Department of Systems Medicine, University of Tor Vergata, Viale Oxford 81, 00133, Rome, Italy.
Giacomo KochDepartment of Clinical and Behavioural Neurology, Santa Lucia Foundation IRCCS, 0039, Rome, Italy.
University of Rome Tor Vergata · ITUniversità degli Studi eCampus · ITUniversity of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo explore whether temporal lobe atrophy predicts 3-month functional outcome in a population of patients with anterior circulation acute ischemic stroke (AIS) treated with mechanical thrombectomy (MT).

methodsWe retrospectively selected patients > 65 years from our prospective endovascular stroke registry between June 2013 and August 2018. According to 3-month modified Rankin Scale (mRS), patients were divided in two groups, named good (mRS ≤ 2) and poor (mRS > 2) outcome. Measures of temporal lobe atrophy (i.e., interuncal distance [IUD], medial temporal lobe thickness [mTLT] and radial width of temporal horn [rWTH]) were assessed on pre-treatment CT scan. Cutoff values for good outcome were obtained for IUD, mTLT and rWTH by means of non-parametric ROC curve analysis. Multivariate analysis was performed to identify predictors of outcome. Ordinal shift analysis based on cutoff values was built to evaluate differences in 3-month mRS.

resultsAmong 340 patients, 130 (38.2%) had good and 210 (61.8%) had poor outcome. We found the following cutoff values for good outcome: < 25 mm for IUD, > 15 mm for mTLT and < 4 mm for rWTH. Lower IUD (OR 0.71; 95% CI 0.63-0.80; p < 0.0001) and rWTH (OR 0.73; 95% CI 0.61-0.87; p < 0.0001) and higher mTLT (OR 1.30; 95% CI 1.14-1.49; p < 0.0001) were independently associated with good outcome. Ordinal shift analysis based on cutoff values revealed significant differences in the rate of good outcome for rWTH (49 vs 27%; p < 0.0001), mTLT (52 vs 21%; p < 0.0001) and IUD (57 vs 17%; p < 0.0001).

conclusionsAssessment of temporal lobe atrophy may predict functional outcome in patients with AIS treated with MT.

Indexed as

Brain IschemiaIschemic StrokeStrokeAgedAtrophyHumansProspective StudiesRetrospective StudiesTemporal LobeThrombectomyTreatment OutcomeAcute strokeBrain atrophyOlder adultPrognosis

Identifiers

PMID36637792
OpenAlexW4315927964

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.