Evidence map›Paper›PMID 36637685›Full record

ArticlePharmacological reports : PR2023

Agonistic properties of a series of psychotropic drugs at 5-HT

Yuji Odagaki, Masaki Mikami, Masakazu Kinoshita, J Javier Meana, Luis F Callado, Jesús A García-Sevilla, Dasiel Oscar Borroto-Escuela, Kjell Fuxe

Abstract read
PubMed Publisher
In one paragraph

Article in Pharmacological reports : PR, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.1field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 1 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Yuji OdagakiDepartment of Psychiatry, Faculty of Medicine, Saitama Medical University, 38 Morohongo, Moroyama-machi, Iruma-gun, 350-0495, Saitama, Japan. yuji0612forward@yahoo.co.jp.ORCID http://orcid.org/0000-0002-1792-028X
Masaki MikamiMedical Student, Faculty of Medicine, Saitama Medical University, 38 Morohongo, Moroyama-machi, Iruma-gun, 350-0495, Saitama, Japan.
Masakazu KinoshitaDepartment of Psychiatry, Faculty of Medicine, Saitama Medical University, 38 Morohongo, Moroyama-machi, Iruma-gun, 350-0495, Saitama, Japan.
J Javier MeanaDepartment of Pharmacology, University of the Basque Country, UPV/EHU, 48940, Leioa, Bizkaia, Spain.ORCID http://orcid.org/0000-0002-7913-6714
Luis F CalladoDepartment of Pharmacology, University of the Basque Country, UPV/EHU, 48940, Leioa, Bizkaia, Spain.ORCID http://orcid.org/0000-0001-9941-012X
Jesús A García-SevillaLaboratory of Neuropharmacology, IUNICS/IdISPa, University of the Balearic Islands (UIB), Palma de Mallorca, Spain.ORCID http://orcid.org/0000-0001-5143-2442
Dasiel Oscar Borroto-EscuelaDepartment of Neuroscience, Biomedicum, Karolinska Institute, 171 77, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-5736-373X
Kjell FuxeDepartment of Neuroscience, Biomedicum, Karolinska Institute, 171 77, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-8491-4288
Karolinska Institutet · SESaitama Medical University · JPUniversity of the Basque Country · ESResearch Institute of Health Sciences · ESTokyo Institute of Psychiatry · JP

Funding

Basque Government IT1512/22Educational Program of Saitama Medical University for Research Mind Promotion of Undergraduates UH34-01Spanish State Research Agency and EDR Funds 201129918Spanish State Research Agency and EDR Funds PID2019-106404RB-100Spanish State Research Agency and EDR Funds SAF-2017-88126-R
6 · The paper itself

Abstract

backgroundMany psychoactive compounds have been developed to have more beneficial clinical efficacy than conventional drugs by adding agonistic action at 5-HT

methodsThe [

resultsThe specific binding was stimulated by brexpiprazole in rat hippocampus, human hippocampus, and human prefrontal cortex. Aripiprazole also behaved as an agonist in the same brain regions. Interestingly, its potency was much higher in rat hippocampal membranes than in human brain membranes, indicating the possibility of species differences. Although vortioxetine was an efficacious stimulator at high concentrations, its potency was undeterminable because of a lack of saturability. In addition to 5-HT

conclusionsOur previous studies have raised the concept of a psychoactive drug group with a common pharmacological mechanism of action, i.e., 5-HT

Indexed as

Receptor, Serotonin, 5-HT1ASerotoninAnimalsAripiprazoleBrainDibenzocycloheptenesGuanosine 5'-O-(3-Thiotriphosphate)HumansLurasidone HydrochloridePsychotropic DrugsQuinolonesRatsSerotonin Receptor AgonistsThiophenesVortioxetineAripiprazoleasenapinebrexpiprazoleDibenzocycloheptenesGuanosine 5'-O-(3-Thiotriphosphate)Lurasidone HydrochloridePsychotropic DrugsQuinolonesReceptor, Serotonin, 5-HT1ASerotoninSerotonin Receptor AgonistsThiophenesVortioxetineBrexpiprazoleG-proteinPsychotropic drugSerotonin 5-HT1A receptorVortioxetine

Identifiers

PMID36637685
OpenAlexW4315865600

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.