Evidence map›Paper›PMID 36637582›Full record

ArticleClinical and experimental medicine2023

The non-invasive diagnosis of colorectal cancer via a SOX9-based gene panel.

Vivian Weiwen Xue, Simon Siu Man Ng, Hin Fung Tsang, Heong Ting Wong, Wing Wa Leung, Yee Ni Wong, Yin Kwan Evelyn Wong, Allen Chi Shing Yu, Aldrin Kay Yuen Yim, William Chi Shing Cho and 2 more

Abstract read
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In one paragraph

Article in Clinical and experimental medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Vivian Weiwen Xue *Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong Special Administrative Region, China.
Simon Siu Man Ng *Department of Surgery, Faculty of Medicine, The Chinese University of Hong Kong, Kowloon, Hong Kong Special Administrative Region, China.
Hin Fung TsangDepartment of Health Technology and Informatics, The Hong Kong Polytechnic University, Kowloon, Hong Kong Special Administrative Region, China.
Heong Ting WongDepartment of Pathology, Kiang Wu Hospital, Santo António, Macau Special Administrative Region, China.
Wing Wa LeungDepartment of Surgery, Faculty of Medicine, The Chinese University of Hong Kong, Kowloon, Hong Kong Special Administrative Region, China.
Yee Ni WongDepartment of Surgery, Faculty of Medicine, The Chinese University of Hong Kong, Kowloon, Hong Kong Special Administrative Region, China.
Yin Kwan Evelyn WongDepartment of Health Technology and Informatics, The Hong Kong Polytechnic University, Kowloon, Hong Kong Special Administrative Region, China.
Allen Chi Shing YuCodex Genetics Limited, Kowloon, Hong Kong Special Administrative Region, China.
Aldrin Kay Yuen YimCodex Genetics Limited, Kowloon, Hong Kong Special Administrative Region, China.
William Chi Shing ChoDepartment of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong Special Administrative Region, China.
William Chi Shing TaiDepartment of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong Special Administrative Region, China.
Sze Chuen Cesar WongDepartment of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong Special Administrative Region, China. cesar.wong@polyu.edu.hk.ORCID https://orcid.org/0000-0003-0058-140X
Hong Kong Polytechnic University · HKChinese University of Hong Kong · HKHospital Authority · HKKiang Wu Hospital · CN

Funding

HK Innovation and Technology Fund University-Industry Collaborative Programme UIM/354National Natural Science Foundation of China 82103438Research Grants Council HK RGCQ71P
6 · The paper itself

Abstract

Colorectal cancer (CRC) threatens human health seriously. Early diagnosis of CRC is critical to improving patient survival. Meanwhile, non-invasive detection through tumor-circulating markers can be an important auxiliary diagnosis. In this study, we performed targeted RNA sequencing in paired tumor and adjacent normal fresh frozen tissues from 68 patients, and we also measured circulating mRNA levels in 4 time-point plasma samples collected before and after operation or chemotherapy. Our results showed that SOX9 (6.73-fold with adjusted p value < 1 × 10

Indexed as

Colorectal NeoplasmsATPases Associated with Diverse Cellular ActivitiesBiomarkers, TumorCarrier ProteinsDNA HelicasesEarly Detection of CancerFrizzled ReceptorsGene Expression Regulation, NeoplasticHumansRNA, MessengerSOX9 Transcription FactorATPases Associated with Diverse Cellular ActivitiesBiomarkers, TumorCarrier ProteinsDNA HelicasesFrizzled ReceptorsFZD4 protein, humanRNA, MessengerRUVBL1 protein, humanSOX9 protein, humanSOX9 Transcription FactorCirculating mRNAColorectal cancerNon-invasive diagnosisTargeted RNA sequencing

Identifiers

PMID36637582
OpenAlexW4315871769

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.