Evidence map›Paper›PMID 36637490›Full record

ArticleAesthetic plastic surgery2023

Platelet-Rich Plasma for Treatment of Hair Loss Improves Patient-Reported Quality of Life.

Abigail Meyers, Alison Jin, Grzegorz J Kwiecien, James Gatherwright, Shilpi Khetarpal, James E Zins

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Article in Aesthetic plastic surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Effectiveness of platelet-rich plasma in treating female hair loss: A systematic review and meta-analysis of randomized controlled trials.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024
    Pooled it
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Abigail MeyersDepartment of Plastic Surgery, A60, Cleveland Clinic, Cleveland, OH, USA.
Alison JinDepartment of Plastic Surgery, A60, Cleveland Clinic, Cleveland, OH, USA.
Grzegorz J KwiecienDepartment of Plastic Surgery, A60, Cleveland Clinic, Cleveland, OH, USA.
James GatherwrightDepartment of Plastic Surgery, A60, Cleveland Clinic, Cleveland, OH, USA.
Shilpi KhetarpalDepartment of Dermatology, Cleveland Clinic, Cleveland, OH, USA.
James E ZinsDepartment of Plastic Surgery, A60, Cleveland Clinic, Cleveland, OH, USA. zinsj@ccf.org.ORCID 0000-0001-8926-7876

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWhile numerous studies have demonstrated enhanced hair growth following platelet-rich plasma (PRP) treatments in patients with male and female pattern hair loss, no study has demonstrated its impact on quality of life (QoL) using a validated tool.

objectiveThis prospective study aimed to assess the psychological impact of PRP treatment for hair loss.

methodsPRP scalp injections were repeated monthly for the first 3 months, then quarterly for 1 year, and annually thereafter. HAIRDEX 48, a validated scale assessing QoL for patients with alopecia, was administered before PRP and at each visit. Scores were interpolated on a 0-100 scale: 0 representing highest QoL, 100 lowest, and compared using paired t-tests.

resultsNinety-two patients receiving PRP were analyzed. Mean age was 48.2 ± 17.4 years and 55% were male. Patients had an average of 4 ± 2 treatments; most (60%) had ≥4. Thirty patients (33%) completed both pre- and post-PRP questionnaires. Prior to PRP, 61% tried minoxidil, 16% finasteride, and 1% hair transplant. Total HAIRDEX scores improved from a mean of 23.2 ± 15.4 to 19.7 ± 11.3 after 3-5 months after PRP (p < 0.001). There were also decreases in symptoms (10.0 ± 12.0 vs. 9.6 ± 10.8, p < 0.001), functioning (16.1 ± 18.1 vs. 13.3 ± 12.6, p < 0.001), and emotions domains (37.7 ± 24.1 vs. 32.2 ± 18.9, p < 0001). For stigmatization and self-confidence domains, improvements from pre-PRP were significant at 3-5 months (21.2 ± 16.8 vs. 17.4 ± 12.1; p < 0.001 and 24.8 ± 17.7 vs. 20.9 ± 15.5; p < 0.001, respectively) and >6 months (18.9 ± 13.9; p < 0.001 and19.5 ± 18.6; p = 0.008, respectively).

conclusionsPRP improves QoL and is an effective part of multimodal therapy for hair loss. LEVEL OF EVIDENCE IV: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

Indexed as

Platelet-Rich PlasmaQuality of LifeAdultAgedAlopeciaFemaleHumansMaleMiddle AgedPatient Reported Outcome MeasuresProspective StudiesTreatment OutcomeAlopeciaBaldnessHair lossHair regrowthPlatelet-rich plasmaPRP

Identifiers

PMID36637490

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.