Evidence map›Paper›PMID 36637439›Full record

ArticleJournal of medicinal food2023

Sodium Propionate or Sodium Butyrate Promotes Fatty Acid Oxidation in HepG2 Cells Under Oxidative Stress.

Kristina J Cook, Ann Coulter, Michael Keenan, Frank Greenway, Jack N Losso

Open access · greenAbstract read
In one paragraph

Article in Journal of medicinal food, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Dietary therapy of murine primary biliary cholangitis induces hepatocellular steatosis: A cautionary tale.Liver international : official journal of the International Association for the Study of the Liver · 2024
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Kristina J CookPennington Biomedical Research Center, Louisisna State University System, Baton Rouge, Louisiana, USA.ORCID 0000-0002-8644-8927
Ann CoulterSchool of Nutrition and Food Sciences, Louisisna State University System, Baton Rouge, Louisiana, USA.ORCID 0000-0002-3103-601X
Michael KeenanPennington Biomedical Research Center, Louisisna State University System, Baton Rouge, Louisiana, USA.ORCID 0000-0003-1282-8756
Frank GreenwaySchool of Nutrition and Food Sciences, Louisisna State University System, Baton Rouge, Louisiana, USA.ORCID 0000-0002-1766-6111
Jack N LossoPennington Biomedical Research Center, Louisisna State University System, Baton Rouge, Louisiana, USA.ORCID 0000-0002-8187-7757
Louisiana State University System · USPennington Biomedical Research Center · US

Funding

Tracking & Evaluation CoreU54GM104940 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Peter Todd Katzmarzyk · 2012 to 2026
$69.1M
NIGMS NIH HHS U54 GM104940
6 · The paper itself

Abstract

The beneficial effects of sodium butyrate (NaB) and sodium propionate (NaP) on fatty acid oxidation (FAO) genes and production of proinflammatory cytokines related to nonalcoholic fatty liver disease (NAFLD) were evaluated using HepG2 human liver hepatocellular carcinoma cells exposed to palmitate/oleate or lipopolysaccharides (LPSs) as a model. The results showed that NaP or NaB was able to promote FAO, regulate lipolysis, and reduce reactive oxygen species production by significantly increasing the mRNA expression of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1

Indexed as

Non-alcoholic Fatty Liver DiseaseButyric AcidHep G2 CellsHumansLipopolysaccharidesOleic AcidOxidative StressPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPPAR alphaPropionatesRNA, MessengerTumor Necrosis Factor-alphaButyric AcidLipopolysaccharidesOleic AcidPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPPAR alphaPropionatesRNA, Messengersodium propionateTumor Necrosis Factor-alphabutyratefatty acid oxidationHepG2 cellsoxidative stresspropionate

Identifiers

PMID36637439
PMCPMC9889010
OpenAlexW4315928246

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.