Evidence map›Paper›PMID 36637224›Full record

ArticleCanadian journal of psychiatry. Revue canadienne de psychiatrie2023

Neuropsychiatric Symptom Burden across Neurodegenerative Disorders and its Association with Function.

Daniel Kapustin, Shadi Zarei, Wei Wang, Malcolm A Binns, Paula M McLaughlin, Agessandro Abrahao, Sandra E Black, Michael Borrie, David Breen, Leanna Casaubon and 36 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

  1. Psychiatry in neurodegenerative disease: toward a unified neurobiological framework.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  2. Article
  3. Understanding the Role of Neuropsychiatric Symptoms in Functional Decline in Alzheimer's Disease.The Journal of neuropsychiatry and clinical neurosciences · 2026
    Article
  4. Functional capacity in Peruvian people with Alzheimer's disease and frontotemporal dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  5. Article
  6. Article
  7. Practical Assessment of Neuropsychiatric Symptoms: Updated Reliability, Validity, and Cutoffs for the Neuropsychiatric Inventory Questionnaire.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2025
    Observational
  8. Article
  9. Neuropsychiatric Symptom Profile in Alzheimer's Disease and Their Relationship With Functional Decline.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2024
    Article
  10. Article
  11. Frontotemporal-spectrum disorders and functional independence in non-demented ALS patients.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Article
  12. Article
  13. Article
  14. Caregiver Burden in Prion Disease.Dementia and geriatric cognitive disorders extra
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

46 authors at 16 institutions in 3 countries.

Daniel KapustinDepartment of Psychiatry, University of Toronto, Toronto, ON, Canada.ORCID 0000-0001-5440-2257
Shadi ZareiDepartment of Psychiatry, University of Toronto, Toronto, ON, Canada.
Wei WangAdult Neurodevelopmental and Geriatric Psychiatry Division, Centre for Addiction and Mental Health, Toronto, ON, Canada.ORCID 0000-0002-0336-506X
Malcolm A BinnsDalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Paula M McLaughlinNova Scotia Health, Halifax, Nova Scotia, Canada.
Agessandro AbrahaoDivision of Neurology, Department of Medicine, University of Toronto, Ontario, Canada.
Sandra E BlackDivision of Neurology, Department of Medicine, University of Toronto, Ontario, Canada.
Michael BorrieUniversity of Western Ontario, London, ON, Canada.
David BreenCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Leanna CasaubonDivision of Neurology, Department of Medicine, University of Toronto, Ontario, Canada.
Dar DowlatshahiDepartment of Medicine (Neurology), University of Ottawa Brain and Mind Institute and Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Elizabeth FingerUniversity of Western Ontario, London, ON, Canada.
Corinne E FischerDepartment of Psychiatry, University of Toronto, Toronto, ON, Canada.
Andrew FrankUniversity of Ottawa, Ottawa, ON, Canada.
Morris FreedmanRotman Research Institute at Baycrest Health Sciences, Toronto, ON, Canada.
David GrimesDepartment of Medicine (Neurology), University of Ottawa Brain and Mind Institute and Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Ayman HassanThunder Bay Regional Research Institute, Northern Ontario School of Medicine, ON, Canada.
Mandar JogUniversity of Western Ontario, London, ON, Canada.
Donna KwanQueen's University, Kingston, ON, Canada.
Anthony LangDivision of Neurology, Department of Medicine, University of Toronto, Ontario, Canada.
Brian LevineDivision of Neurology, Department of Medicine, University of Toronto, Ontario, Canada.
Jennifer MandziaUniversity of Western Ontario, London, ON, Canada.
Connie MarrasDivision of Neurology, Department of Medicine, University of Toronto, Ontario, Canada.
Mario MasellisDivision of Neurology, Department of Medicine, University of Toronto, Ontario, Canada.
Joseph B OrangeCanadian Centre for Activity and Aging, Western University, ON, Canada.
Stephen PasternakUniversity of Western Ontario, London, ON, Canada.
Alicia PeltschQueen's University, Kingston, ON, Canada.
Bruce G PollockDepartment of Psychiatry, University of Toronto, Toronto, ON, Canada.
Tarek K RajjiDepartment of Psychiatry, University of Toronto, Toronto, ON, Canada.
Angela RobertsSchool of Communication, Northwestern University, Evanston, Illinois, USA.
Demetrios SahlasMcMaster University, Hamilton, ON, Canada.
Gustavo SaposnikDivision of Neurology, Department of Medicine, University of Toronto, Ontario, Canada.
Dallas SeitzDepartment of Psychiatry and Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Christen ShoesmithDivision of Neurology, Department of Clinical Neurological Sciences, London Health Sciences Centre, London, ON, Canada.
Alisia SouthwellSunnybrook Health Sciences Centre, Toronto, ON, Canada.
Thomas D L SteevesDivision of Neurology, Department of Medicine, University of Toronto, Ontario, Canada.
Kelly SunderlandRotman Research Institute at Baycrest Health Sciences, Toronto, ON, Canada.
Richard H SwartzDivision of Neurology, Department of Medicine, University of Toronto, Ontario, Canada.
Brian TanRotman Research Institute at Baycrest Health Sciences, Toronto, ON, Canada.
David F Tang-WaiDivision of Neurology, Department of Medicine, University of Toronto, Ontario, Canada.
Maria Carmela TartagliaDivision of Neurology, Department of Medicine, University of Toronto, Ontario, Canada.
Angela TroyerDivision of Neurology, Department of Medicine, University of Toronto, Ontario, Canada.
John TurnbullMcMaster University, Hamilton, ON, Canada.
Lorne ZinmanDivision of Neurology, Department of Medicine, University of Toronto, Ontario, Canada.
ONDRI investigators
Sanjeev KumarDepartment of Psychiatry, University of Toronto, Toronto, ON, Canada.
Centre for Addiction and Mental Health · CAUniversity of Toronto · CASunnybrook Health Science Centre · CAWestern University · CAUniversity of Ottawa · CAUniversity Health Network · CABaycrest Hospital · CAMcMaster University · CAQueen's University · CALondon Health Sciences Centre · CANorthwestern University · USNova Scotia Health Authority · CASt. Michael's Hospital · CAThunder Bay Regional Research Institute · CAUniversity of Calgary · CAUniversity of Edinburgh · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveNeuropsychiatric symptoms (NPS) are prevalent in neurodegenerative disorders, however, their frequency and impact on function across different disorders is not well understood. We compared the frequency and severity of NPS across Alzheimer's disease (AD) (either with mild cognitive impairment or dementia), Cerebrovascular disease (CVD), Parkinson's disease (PD), frontotemporal dementia (FTD), and amyotrophic lateral sclerosis (ALS), and explored the association between NPS burden and function.

methodsWe obtained data from Ontario Neurodegenerative Disease Research Initiative (ONDRI) that included following cohorts: AD (

resultsFrequency of NPS varied across cohorts (χ

conclusionsNPS frequency and severity are markedly greater in FTD as compared to other neurodegenerative diseases. Further, NPS burden appears to be associated differently with function across neurodegenerative disorders, highlighting the need for individualized clinical interventions.

Indexed as

Alzheimer DiseaseAmyotrophic Lateral SclerosisCardiovascular DiseasesFrontotemporal DementiaNeurodegenerative DiseasesHumansagingaging and memoryAlzheimer's diseasecohort studygeriatric psychiatry

Identifiers

PMID36637224
PMCPMC10192827
OpenAlexW4315927898

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.