Evidence map›Paper›PMID 36637125›Full record

ArticleThe Journal of infectious diseases2023

Upregulation of PTPRC and Interferon Response Pathways in HIV-1 Seroconverters Prior to Infection.

Yunqi Li, Francois Lefebvre, Edith Nakku-Joloba, Allan Ronald, Glenda Gray, Guy de Bruyn, James Kiarie, Connie Celum, Mark J Cameron, Jairam R Lingappa and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Natural Resistance to HIV Infection: Role of Immune Activation.Immunity, inflammation and disease · 2025
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yunqi LiInstitute for Public Health Genetics, University of Washington, Seattle, Washington, USA.ORCID 0000-0002-8887-9691
Francois LefebvreCanadian Centre for Computational Genomics-Montréal Node, Montreal, Quebec, Canada.
Edith Nakku-JolobaSchool of Public Health, Makerere University, Kampala, Uganda.
Allan RonaldDepartment of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Canada.
Glenda GrayPerinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa.
Guy de BruynPerinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa.
James KiarieDepartment of Obstetrics and Gynecology, University of Nairobi, Nairobi, Kenya.
Connie CelumDepartment of Global Health, University of Washington, Seattle, Washington, USA.
Mark J CameronDepartment of Population and Quantitative Health Science, Case Western Reserve University, Cleveland, Ohio, USA.
Jairam R LingappaDepartment of Global Health, University of Washington, Seattle, Washington, USA.
Romel D MackelprangDepartment of Global Health, University of Washington, Seattle, Washington, USA.

Funding

Identification of drug-targetable IFN-stimulated genes mediating immune activation during ART-treated HIV-1 infectionR01AI134293 · NIAID · UNIVERSITY OF WASHINGTON · PI MACKELPRANG, ROMEL D · 2018 to 2022
$3.6M
mRNA/miRNA Regulation of Host Resistance and Control in HIV-1 Discordant CouplesR21AI087427 · NIAID · UNIVERSITY OF WASHINGTON · PI LINGAPPA, JAIRAM RAO · 2010 to 2011
$454k
NIAID NIH HHS R01 AI134293NIH HHS 5R21AI087427-02
6 · The paper itself

Abstract

Human immunodeficiency virus 1 (HIV-1) exposed seronegative (HESN) individuals may have unique characteristics that alter susceptibility to HIV-1 infection. However, identifying truly exposed HESN is challenging. We utilized stored data and biospecimens from HIV-1 serodifferent couple cohorts, in which couples' HIV-1 exposures were quantified based on unprotected sex frequency and viral load of the partner with HIV-1. We compared peripheral blood gene expression between 15 HESN and 18 seroconverters prior to infection. We found PTPRC (encoding CD45 antigen) and interferon-response pathways had significantly higher expression among individuals who went on to become seropositive and thus may be a signature for increased acquisition risk.

Indexed as

HIV-1HIV InfectionsHumansInterferonsLeukocyte Common AntigensUp-RegulationInterferonsLeukocyte Common AntigensPTPRC protein, humanacquisitiongene expressionHIV-1host resistancemicroarray

Identifiers

PMID36637125
PMCPMC9978315

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.