ArticleGenes, brain, and behavior2023
The Drosophila dopamine 2-like receptor D2R (Dop2R) is required in the blood brain barrier for male courtship.
Article in Genes, brain, and behavior, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 13 citations in OpenAlex.
- Oral intake of aripiprazole compromises male fertility in Drosophila.Biology direct · 2025Article
- Feminization of the Blood-Brain Barrier Changes the Brain Transcriptome ofCurrent issues in molecular biology · 2025Article
- Genome-wide identification and functional characterization of GPCR family genes reveal their key roles in the vitellarium development and egg production in Schistosoma japonicum.Parasites & vectors · 2025Article
- Experimental Evolution Induced by Maternal Post-copulatory Factors in Drosophila.Behavior genetics · 2025Article
- A novel method for identifying key genes in macroevolution based on deep learning with attention mechanism.Scientific reports · 2023Article
- The Drosophila dopamine 2-like receptor D2R (Dop2R) is required in the blood brain barrier for male courtship.Genes, brain, and behavior · 2023Article
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5 authors at 2 institutions in 1 country.
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Abstract
The blood brain barrier (BBB) has the essential function to protect the brain from potentially hazardous molecules while also enabling controlled selective uptake. How these processes and signaling inside BBB cells control neuronal function is an intense area of interest. Signaling in the adult Drosophila BBB is required for normal male courtship behavior and relies on male-specific molecules in the BBB. Here we show that the dopamine receptor D2R is expressed in the BBB and is required in mature males for normal mating behavior. Conditional adult male knockdown of D2R in BBB cells causes courtship defects. The courtship defects observed in genetic D2R mutants can be rescued by expression of normal D2R specifically in the BBB of adult males. Drosophila BBB cells are glial cells. Our findings thus identify a specific glial function for the DR2 receptor and dopamine signaling in the regulation of a complex behavior.
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