ArticleEMBO molecular medicine2023
Interferon regulates neural stem cell function at all ages by orchestrating mTOR and cell cycle.
Article in EMBO molecular medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Harnessing biological variability for mechanistic inference: A stochastic framework applied to neural stem cell dynamics.iScience · 2026Article
- Regeneration of the mammalian brain: a relic of evolution?Stem cells (Dayton, Ohio) · 2026Review
- TNF-α induces type I IFN signalling to suppress neurogenesis and recruit T cells.Nature communications · 2026Article
- Targeting immune cells in the aged brain reveals that engineered cytokine IL-10 enhances neurogenesis and improves cognition.Immunity · 2026Article
- How stem cells respond to infection, inflammation and ageing.Nature reviews. Immunology · 2025Review
- Programmed cell revival from imminent cell death enhances tissue repair and regeneration.The EMBO journal · 2025Article
- Cross-species comparison reveals therapeutic vulnerabilities halting glioblastoma progression.Nature communications · 2025Article
- Unraveling regulatory feedback mechanisms in adult neurogenesis through mathematical modelling.NPJ systems biology and applications · 2025Article
- Neural stem cell relay from B1 to B2 cells in the adult mouse ventricular-subventricular zone.Cell reports · 2025Article
- Significance of birth in the maintenance of quiescent neural stem cells.Science advances · 2025Article
- Ex vivo study of neuroinvasive and neurotropic viruses: what is current and what is next.FEMS microbiology reviews · 2025Review
- Beyond the canonical niche: how astrocytes carried neurogenic potential into the brain parenchyma.Frontiers in cell and developmental biology · 2025Review
- Astrocytes originated from neural stem cells drive the regenerative remodeling of pathologic CSPGs in spinal cord injury.Stem cell reports · 2024Article
- Article
- 3D printing of interferon γ-preconditioned NSC-derived exosomes/collagen/chitosan biological scaffolds for neurological recovery after TBI.Bioactive materials · 2024Article
- Single-cell RNA sequencing of aging neural progenitors reveals loss of excitatory neuron potential and a population with transcriptional immune response.Frontiers in neuroscience · 2024Article
- Nerve regeneration by interferon intervention in aging brain.EMBO molecular medicine · 2023Article
- Article
- CycleFlow simultaneously quantifies cell-cycle phase lengths and quiescenceCell reports methods · 2022Article
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16 authors.
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Abstract
Stem cells show intrinsic interferon signalling, which protects them from viral infections at all ages. In the ageing brain, interferon signalling also reduces the ability of stem cells to activate. Whether these functions are linked and at what time interferons start taking on a role in stem cell functioning is unknown. Additionally, the molecular link between interferons and activation in neural stem cells and how this relates to progenitor production is not well understood. Here we combine single-cell transcriptomics, RiboSeq and mathematical models of interferon to show that this pathway is important for proper stem cell function at all ages in mice. Interferon orchestrates cell cycle and mTOR activity to post-transcriptionally repress Sox2 and induces quiescence. The interferon response then decreases in the subsequent maturation states. Mathematical simulations indicate that this regulation is beneficial for the young and harmful for the old brain. Our study establishes molecular mechanisms of interferon in stem cells and interferons as genuine regulators of stem cell homeostasis and a potential therapeutic target to repair the ageing brain.
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Registered trials
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