ArticleClinical epidemiology2023
Completeness and Representativeness of the PHARMO General Practitioner (GP) Data: A Comparison with National Statistics.
Article in Clinical epidemiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Sex differences in single and combined cardiovascular medication use.American heart journal plus : cardiology research and practice · 2026Article
- GP Consultations for Herpes Zoster After COVID-19 Vaccination: A Self-Controlled Cohort Study Based on Electronic Health Record Data from the Netherlands.Drug safety · 2026Article
- Real-world evaluation of clinical outcomes in Dutch patients with type 2 diabetes treated with oral semaglutide: A retrospective, observational cohort study using the PHARMO data network.Diabetes, obesity & metabolism · 2026 · on this mapObservational
- GP Consultations for Venous Thromboembolism (VTE) After mRNA and Adeno-Vector-Based COVID-19 Vaccination-An Exposure-Anchored Self-Controlled Cohort Study Based on Primary Healthcare Data From the Netherlands.Pharmacoepidemiology and drug safety · 2026Article
- Uptitration of statin therapy in women and men: a population-based cohort study.European heart journal. Quality of care & clinical outcomes · 2025Article
- Natural course of subclinical hyperthyroidism in primary care in the Netherlands.European thyroid journal · 2025Article
- General practitioner consultation for postmenopausal bleeding after COVID-19 vaccination-a self-controlled cohort study.British journal of clinical pharmacology · 2025Article
- Implications of Data Extraction and Processing of Electronic Health Records for Epidemiological Research: Observational Study.Journal of medical Internet research · 2025Observational
- Article
- Trends in initial pharmacological COPD treatment in primary care (2010-2021): a population-based study using the PHARMO Data Network.Respiratory research · 2024Article
- Antihypertensive medication classes and risk of incident dementia in primary care patients: a longitudinal cohort study in the Netherlands.The Lancet regional health. Europe · 2024Article
- Type 2 Diabetes, the Epidemic: Trends in Prevalence and Incidence, 2004-2020.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Risk of cardiovascular events after an exacerbation of chronic obstructive pulmonary disease: results from the EXACOS-CV cohort study using the PHARMO Data Network in the Netherlands.Respiratory research · 2023Article
- Prevalence of chronic kidney disease in the Netherlands and its cardiovascular and renal complications.BMC nephrology · 2023Article
- Incidence of Lyme Borreliosis in the Dutch General Practice Population: A Large-Scale Population-Based Cohort Study Across the Netherlands Between 2015 and 2019.Vector borne and zoonotic diseases (Larchmont, N.Y.) · 2023Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: When using incomplete or non-representative real-world data (RWD), bias is more likely to occur. The aim of the current study was to assess the completeness and representativeness of the PHARMO GP data for the Dutch population. Patients and Methods: A cross-sectional study was performed. The PHARMO GP data comprise data from electronic health records registered by GPs. Data on the Dutch population were obtained from Statistics Netherlands (CBS), which offers publicly available data on several themes. The standardized difference (std.diff) was used to compare proportions between the PHARMO GP population and the Dutch population. An absolute std.diff >0.2 was considered a difference. Results: On January 1st, 2018, 3,466,321 persons were included in the PHARMO GP data (mean age: 41.6 years, 49.7% males). The sex and age distribution was similar to the Dutch population. The PHARMO GP data captured less not urbanized areas compared to the Dutch population (not urbanized areas: 9.4% vs 17.1% [std.diff: -0.23]). Regarding medication use, only the pharmacological subgroups "viral vaccines" and "hormonal contraceptives for systemic use" differed (std.diff >0.2); use in the GP data was more complete than in the Statistics Netherlands (CBS) data. No differences were observed regarding diagnoses. Conclusion: The PHARMO GP data are representative of the Dutch population with regard to the demographic characteristics and diagnoses in primary care. Medication data in the PHARMO GP data are more complete than national statistics, and differences are related to reimbursement. Use of the data and interpretation of results based on these sources should be done with experts on the data sources, the Dutch healthcare system and (pharmaco)epidemiology.
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