Evidence map›Paper›PMID 36636671›Full record

ArticleCase reports in oncology

Adult T-Cell Leukemia-Lymphoma Presenting Concurrently with Myelopathy.

Sneha Poondru, Ancy Joseph, John C Harding, Hemalatha Sundaramoorthi, Neha Mehta-Shah, Patrick Green, Anjum Hassan, Daniel A Rauch, Lee Ratner

Open access · goldAbstract readCase Reports
In one paragraph

Article in Case reports in oncology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 59% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Sneha PoondruSchool of Medicine, University of Missouri-Kansas City, Kansas City, Missouri, USA.
Ancy JosephDivision of Oncology, Washington University School of Medicine, St Louis, Missouri, USA.
John C HardingDivision of Oncology, Washington University School of Medicine, St Louis, Missouri, USA.
Hemalatha SundaramoorthiDivision of Oncology, Washington University School of Medicine, St Louis, Missouri, USA.
Neha Mehta-ShahDivision of Oncology, Washington University School of Medicine, St Louis, Missouri, USA.
Patrick GreenCenter for Retrovirus Research and Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, USA.
Anjum HassanDepartment of Pathology & Immunology, Washington University School of Medicine, St Louis, Missouri, USA.
Daniel A RauchDivision of Oncology, Washington University School of Medicine, St Louis, Missouri, USA.
Lee RatnerDivision of Oncology, Washington University School of Medicine, St Louis, Missouri, USA.
Washington University in St. Louis · USThe Ohio State University · USUniversity of Missouri–Kansas City · US

Funding

Role of Inflammation in Tax-mediated TumorigenesisP01CA100730 · NCI · WASHINGTON UNIVERSITY · PI Malachi Griffith · 2003 to 2026
$44.8M
NCI NIH HHS P01 CA100730
6 · The paper itself

Abstract

Human T-cell leukemia virus type 1 (HTLV-1) is an oncogenic retrovirus. Of the approximate ten to twenty million people currently infected worldwide, 4-9% of infected individuals develop adult T-cell leukemia/lymphoma (ATLL) or HTLV-associated myelopathy/tropical spastic paresis (HAM/TSP) in their lifetime. The current report is based on a patient who presented concurrently with CD30+ lymphoma subtype ATLL and HAM/TSP. The patient's ATLL responded to brentuximab-vedotin-based chemotherapy; however, HAM/TSP did not improve. The patient's peripheral blood mononuclear cells were cultured and injected into immunodeficient mice, and the mice developed massive organ involvement and chronic lymphocytic leukemia-subtype ATLL. This case study is novel in the findings of concurrent development of ATLL and HAM/TSP, the response to brentuximab-vedotin chemotherapy, and the use HTLV-1 helix basic zipper protein-targeted probe for RNAscope for diagnosis.

Indexed as

Adult T-cell leukemia/lymphomaBrentuximab-vedotinHTLV-associated myelopathy/tropical spastic paresis

Identifiers

PMID36636671
PMCPMC9830276
OpenAlexW4308571824

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.