ArticleACS catalysis2020
Acridine Photocatalysis: Insights into the Mechanism and Development of a Dual-Catalytic Direct Decarboxylative Conjugate Addition.
Article in ACS catalysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Acridine/Lewis acid photocatalysis enables α-amidyl radical cyclizations.Organic chemistry frontiers : an international journal of organic chemistry · 2026Article
- Article
- Acridinium amidate as a hydrogen-bonding photocatalyst for direct decarboxylative alkylation of native carboxylic acids.Chemical science · 2026Article
- Photoredox-Neutral Platform for Direct Decarboxylative CyclopropanationACS catalysis · 2026Article
- Hydrogen bonding mediated electron donor-acceptor acceptor catalysis in hydrosulfonylation and sulfonyl dehydrogenation of olefins.Nature communications · 2026Article
- Dispersion-Enhanced Nitrogen-Centered Photocatalysis of the Direct Hydrogen Atom Transfer.Angewandte Chemie (International ed. in English) · 2026Article
- Cyclic Imine-BFSynlett : accounts and rapid communications in synthetic organic chemistry · 2025Article
- Copper-catalyzed C(spNature communications · 2025Article
- N-Protonated Acridinium Catalyst Enables Anti-Markovnikov Hydration of Unconjugated Tri- and Disubstituted Olefins.Journal of the American Chemical Society · 2025Article
- Iterative One-Carbon Homologation of Unmodified Carboxylic Acids.Journal of the American Chemical Society · 2024Article
- Acridine/Lewis Acid Complexes as Powerful Photocatalysts: A Combined Experimental and Mechanistic Study.ACS catalysis · 2024Article
- Photocatalytic Decarboxylative Alkylation of Cyclic Imine-BFJournal of the American Chemical Society · 2024Article
- Acridine photocatalysis enables tricomponent direct decarboxylative amine construction.Chemical science · 2024Article
- Multimodal Acridine Photocatalysis Enables Direct Access to Thiols from Carboxylic Acids and Elemental Sulfur.ACS catalysis · 2024Article
- Direct conversion of carboxylic acids to free thiolsChemical science · 2024Article
- Photocatalytic α-alkylation of carbamates with vinyl azaarenes.ARKIVOC : free online journal of organic chemistry · 2024Article
- Alkanes in Minisci-Type Reaction under Photocatalytic Conditions with Hydrogen Evolution.Organic letters · 2023Article
- Kinetically-driven reactivity of sulfinylamines enables direct conversion of carboxylic acids to sulfinamides.Chemical science · 2023Article
- Photocatalytic Carboxylate to Sulfinamide Switching Delivers a Divergent Synthesis of Sulfonamides and Sulfonimidamides.Journal of the American Chemical Society · 2023Article
- Direct decarboxylative Giese amidations: photocatalyticChemical science · 2023Article
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7 authors.
Funding
Abstract
Conjugate addition is one of the most synthetically useful carbon‒carbon bond-forming reactions, however, reactive carbon nucleophiles are typically required to effect the addition. Radical conjugate addition provides an avenue for replacing reactive nucleophiles with convenient radical precursors. Carboxylic acids can serve as simple and stable radical precursors by way of decarboxylation, but activation to reactive esters is typically necessary to facilitate the challenging decarboxylation. Here, we report a direct, dual-catalytic decarboxylative radical conjugate addition of a wide range of carboxylic acids that does not require acid preactivation and is enabled by the visible light-driven acridine photocatalysis interfaced with an efficient copper catalytic cycle. Mechanistic and computational studies provide insights into the roles of the ligands and metal species in the dual catalytic process and the photocatalytic activity of substituted acridines.
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