Evidence map›Paper›PMID 36636582›Full record

ArticleMultiple sclerosis journal - experimental, translational and clinical

High fever in myelin oligodendrocyte glycoprotein-associated disorder (MOGAD): A diagnostic challenge.

Chadi Azar, Grace Akiki, Sara F Haddad, Anthony Kerbage, Fady Haddad, Gabrielle Macaron

Abstract readCase Reports
In one paragraph

Article in Multiple sclerosis journal - experimental, translational and clinical. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Characteristics of myelin oligodendrocyte glycoprotein antibody-associated meningoencephalitis.Multiple sclerosis journal - experimental, translational and clinical
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chadi AzarDepartment of Internal Medicine and Clinical Immunology, Hotel Dieu de France Hospital, Saint Joseph University, Beirut, Lebanon.ORCID https://orcid.org/0000-0001-6431-0727
Grace AkikiDepartment of Psychiatry, Hotel Dieu de France Hospital, Saint Joseph University, Beirut, Lebanon.
Sara F HaddadDepartment of Internal Medicine, Hotel Dieu de France Hospital, Saint Joseph University, Beirut, Lebanon.ORCID https://orcid.org/0000-0002-7262-028X
Anthony KerbageDepartment of Internal Medicine, Hotel Dieu de France Hospital, Saint Joseph University, Beirut, Lebanon.ORCID https://orcid.org/0000-0003-3824-9859
Fady HaddadDepartment of Internal Medicine and Clinical Immunology, Hotel Dieu de France Hospital, Saint Joseph University, Beirut, Lebanon.
Gabrielle MacaronDepartment of Neurology, Hotel Dieu de France Hospital, Saint Joseph University, Beirut, Lebanon.ORCID https://orcid.org/0000-0002-7303-2332

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The phenotypic spectrum of myelin oligodendrocyte glycoprotein (MOG)-IgG associated disorders (MOGAD) has broadened in the past few years, and atypical phenotypes are increasingly recognized. Febrile meningoencephalitis has rarely been reported as a feature of MOGAD and represents a diagnostic challenge. We report the case of 24-year-old women with high-grade fever, meningoencephalomyelitis, and persistently positive MOG-IgG, for whom an extensive infectious work-up was negative and who responded to high-dose intravenous methylprednisolone. The full clinical spectrum of MOGAD is yet to be completely elucidated. In patients presenting with febrile meningoencephalitis, MOG-IgG testing should be considered particularly if infectious work-up is negative.

Indexed as

demyelinating diseaseencephalomyelitisfeverMOG-IgG associated disordersrhombencephalitis

Identifiers

PMID36636582
PMCPMC9830568

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.