ArticleiScience2023
Modeling foot sole cutaneous afferents: FootSim.
Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Trends in neuroprosthetic technologies to restore sensations.Biomedical engineering letters · 2026Review
- Neuromorphic Technologies for Neuroengineering: From Adaptive Stimulation to SNN-Based Inference and Deployable Biointerfaces.Sensors (Basel, Switzerland) · 2026Review
- The optimization of neuroprosthetic interfaces relying on biophysical and surrogate digital twins.npj biomedical innovations · 2026Review
- Decoding phantom limb movements from intraneural recordings.Nature communications · 2026Article
- Toward Natural Limb Function: A New Era in Prosthetic Innovation.Annals of neurology · 2025Review
- The extraordinary enigma of ordinary tickle behavior: Why gargalesis still puzzles neuroscience.Science advances · 2025Review
- The Next Frontier in Neuroprosthetics: Integration of Biomimetic Somatosensory Feedback.Biomimetics (Basel, Switzerland) · 2025Review
- Pressure-pain thresholds of the plantar foot reflect relative tissue thickness and are systematically higher in active runners than non-runners.Frontiers in physiology · 2025Article
- Sensory integration for neuroprostheses: from functional benefits to neural correlates.Medical & biological engineering & computing · 2024Review
- NSF DARE-Transforming modeling in neurorehabilitation: Four threads for catalyzing progress.Journal of neuroengineering and rehabilitation · 2024Review
- Neural population dynamics reveals disruption of spinal circuits' responses to proprioceptive input during electrical stimulation of sensory afferents.Cell reports · 2024Article
- Biomimetic computer-to-brain communication enhancing naturalistic touch sensations via peripheral nerve stimulation.Nature communications · 2024Article
- Neuromorphic hardware for somatosensory neuroprostheses.Nature communications · 2024Review
- Complexity of spatio-temporal plantar pressure patterns during everyday behaviours.Journal of the Royal Society, Interface · 2023Article
- Symbiotic electroneural and musculoskeletal framework to encode proprioception via neurostimulation: ProprioStim.iScience · 2023Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While walking and maintaining balance, humans rely on cutaneous feedback from the foot sole. Electrophysiological recordings reveal how this tactile feedback is represented in neural afferent populations, but obtaining them is difficult and limited to stationary conditions. We developed the FootSim model, a realistic replication of mechanoreceptor activation in the lower limb. The model simulates neural spiking responses to arbitrary mechanical stimuli from the combined population of all four types of mechanoreceptors innervating the foot sole. It considers specific mechanics of the foot sole skin tissue, and model internal parameters are fitted using human microneurography recording dataset. FootSim can be exploited for neuroscientific insights, to understand the overall afferent activation in dynamic conditions, and for overcoming the limitation of currently available recording techniques. Furthermore, neuroengineers can use the model as a robust
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