ReviewJournal of inflammation research2023
Pathogenesis and Therapy of Coagulation Disorders in Severe Acute Pancreatitis.
Review in Journal of inflammation research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- Life-threatening upper gastrointestinal bleeding caused by pancreatic pseudocysts: A case report.Medicine · 2026Article
- Development and Validation of an Early Severity Prediction Model for Hypertriglyceridemia-Associated Acute Pancreatitis: A Multicenter Cohort Study.Journal of inflammation research · 2026Article
- EASIX as a moderately effective prognostic marker for mortality in severe acute pancreatitis: a retrospective study.Frontiers in medicine · 2026Article
- Research Progress onMediators of inflammation · 2026Review
- Predicting the acute pancreatitis severity with multi-machine learning models: constructing an online prediction platform.Frontiers in cellular and infection microbiology · 2026Article
- Article
- Mechanistic insights into how intrapancreatic fat deposition drives the development of acute pancreatitis.International journal of biological sciences · 2026Review
- Uncovering new MicroRNAs linked to acute pancreatitis: zeroing in on the protective effect.Hereditas · 2025Article
- Effect of early prophylactic heparin use on prognosis in critically ill patients with acute pancreatitis: a retrospective cohort study.Scientific reports · 2025Article
- Telling Ghost Stories Around a Bonfire-A Literature Review of Acute Bleeding Secondary to Pancreatitis.Medicina (Kaunas, Lithuania) · 2025Review
- Early Prophylactic Anticoagulation and In-Hospital Mortality in Patients with Severe Acute Pancreatitis: A Retrospective Cohort Study.Open access emergency medicine : OAEM · 2025Article
- Practical approach to acute pancreatitis: from diagnosis to the management of complications.Internal and emergency medicine · 2024Review
- The Preventive and Therapeutic Effects of Acute and Severe Inflammatory Disorders with Heparin and Heparinoid.Biomolecules · 2024Review
- A Retrospective Study on the Start and End of Continuous Hemodialysis Using a Polymethylmethacrylate Hemofilter for Severe Acute Pancreatitis.Internal medicine (Tokyo, Japan) · 2024Article
- Establishment and Validation of an Early Predictive Model for Severe Acute Pancreatitis.Journal of inflammation research · 2024Article
- Altered immune cell in human severe acute pancreatitis revealed by single-cell RNA sequencing.Frontiers in immunology · 2024Article
- Interleukins: pathophysiological role in acute pancreatitis.Archives of medical science : AMS · 2024Article
- RNA-sequencing approach for exploring the protective mechanisms of dexmedetomidine on pancreatic injury in severe acute pancreatitis.Frontiers in pharmacology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ischemia superimposed upon pancreatic edema leads to acute necrotizing pancreatitis. One possible mechanism contributing to ischemia is intravascular thrombogenesis since fibrin deposits have been detected in pancreatic capillaries by electron microscope. Current experimental and clinical data provided compelling evidence that the disorders in the blood coagulation system play a critical role in the pathogenesis of severe acute pancreatitis (SAP). This leads to microcirculatory failure of intra- and extrapancreatic organs and multiple organ failure and increases the case fatality rate. However, the mechanism of coagulopathy underlying SAP is not yet clear, although some anticoagulant drugs have entered clinical practice showing improvement in prognosis. Thus, enhanced understanding of the process might improve the treatment strategies with safety and high efficacy. Herein, the pathogenesis of the coagulation system of SAP was reviewed with a focus on the coagulation pathway, intercellular interactions, and complement system, thereby illustrating some anticoagulant therapies and potential therapeutic targets.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.