ArticleTobacco use insights2023
Demographic, Clinical, and Behavioral Factors Associated With Electronic Nicotine Delivery Systems Use in a Large Cohort in the United States.
Article in Tobacco use insights, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Electronic cigarettes and cardiovascular outcomes: a systematic review and meta-analysis of Major Adverse Cardiovascular Events (MACE).BMC public health · 2026Pooled it
- Association between current e-cigarette use and chronic obstructive pulmonary disease: a meta-analysis focusing on exclusive e-cigarette users.Frontiers in public health · 2026Pooled it
- Are electronic cigarettes associated with the risk of myocardial infarction and stroke? A systematic review and meta-analysis.BMC public health · 2025Pooled it
- Association of electronic cigarette use and risk of COPD: a systematic review and meta-analysis.NPJ primary care respiratory medicine · 2025Pooled it
- Population-Based Disease Odds for E-Cigarettes and Dual Use versus Cigarettes.NEJM evidence · 2024Pooled it
- Comparison of e-Cigarette and Cigarette Use and Dual Use Associations With Disease: Updated Systematic Review and Meta-Analysis.Public health reports (Washington, D.C. : 1974)Pooled it
- Inaccurate and misleading meta-analysis of E-cigarettes and population-based diseases.Internal and emergency medicine · 2025Article
- Clinical Impact of Vaping.Toxics · 2025Review
- Comparing smoking-related disease rates from e-cigarette use with those from tobacco cigarette use: a reanalysis of a recently-published study.Harm reduction journal · 2025Article
- Observational studies of exposure to tobacco and nicotine products: Best practices for maximizing statistical precision and accuracy.iScience · 2025Review
- Sexual identity differences in ideal cardiovascular health among cisgender adults in the All of Us Research Program.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2025Article
- Evidence update on the cancer risk of vaping e-cigarettes: A systematic review.Tobacco induced diseases · 2025Review
- Vaping, smoking and risk of early onset lung cancer.Frontiers in oncology · 2025Article
- Association between electronic nicotine delivery systems use and risk of stroke: a meta-analysis of 1,024,401 participants.Archives of medical science : AMS · 2023Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Introduction: Our primary purpose is to understand comorbidities and health outcomes associated with electronic nicotine delivery systems (ENDS) use. Methods: Study participants were Kaiser Permanente (KP) members from eight US regions who joined the Kaiser Permanente Research Bank (KPRB) from September 2015 through December 2019 and completed a questionnaire assessing demographic and behavioral factors, including ENDS and traditional cigarette use. Medical history and health outcomes were obtained from electronic health records. We used multinomial logistic regression to estimate odd ratios (ORs) and 95% confidence intervals (CIs) of current and former ENDS use according to member characteristics, behavioral factors, and clinical history. We used Cox regression to estimate hazard ratios (HRs) and 95% CIs comparing risk of health outcomes according to ENDS use. Results: Of 119 593 participants, 1594 (1%) reported current ENDS use and 5603 (5%) reported past ENDS use. ENDS users were more likely to be younger, male, gay or lesbian, and American Indian / Alaskan Native or Asian. After adjustment for confounding, current ENDS use was associated with current traditional cigarette use (OR = 39.55; CI:33.44-46.77), current marijuana use (OR = 6.72; CI:5.61-8.05), history of lung cancer (OR = 2.64; CI:1.42-4.92), non-stroke cerebral vascular disease (OR = 1.55; CI:1.21-1.99), and chronic obstructive pulmonary disease (OR = 2.16; CI:1.77-2.63). Current ENDS use was also associated with increased risk of emergency room (ER) visits (HR = 1.17; CI: 1.05-1.30) and death (HR = 1.84; CI:1.02-3.32). Conclusions: Concurrent traditional cigarette use, marijuana use, and comorbidities were prevalent among those who used ENDS, and current ENDS use was associated with an increased risk of ER visits and death. Additional research focused on health risks associated with concurrent ENDS and traditional cigarette use in those with underlying comorbidities is needed.
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