Evidence map›Paper›PMID 36635911›Full record

GuidelineEndocrine reviews2023

International Consensus Guideline on Small for Gestational Age: Etiology and Management From Infancy to Early Adulthood.

Anita C S Hokken-Koelega, Manouk van der Steen, Margaret C S Boguszewski, Stefano Cianfarani, Jovanna Dahlgren, Reiko Horikawa, Veronica Mericq, Robert Rapaport, Abdullah Alherbish, Debora Braslavsky and 16 more

Open access · bronzeAbstract readPractice Guideline
In one paragraph

Guideline in Endocrine reviews, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 119 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
119citing papers in PubMed, 4 pooled it
87.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

119 citing papers in PubMed, 4 syntheses or guidelines pooled it, 150 citations in OpenAlex.

  1. Placental Stiffness Measured by Sonoelastography in Fetal Growth Restriction: A Systematic Review and Meta-Analysis.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2026
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59 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 19 institutions in 13 countries.

Anita C S Hokken-KoelegaDepartment of Pediatrics, Subdivision of Endocrinology, Erasmus University Medical Center, 3015 CN Rotterdam, The Netherlands.ORCID 0000-0002-1384-7628
Manouk van der SteenDepartment of Pediatrics, Subdivision of Endocrinology, Erasmus University Medical Center, 3015 CN Rotterdam, The Netherlands.
Margaret C S BoguszewskiDepartment of Pediatrics, Federal University of Parana, 1154 Curitiba, Brazil.
Stefano CianfaraniDepartment of Systems Medicine, University of Rome 'Tor Vergata', 00133 Rome, Italy.
Jovanna DahlgrenDepartment of Pediatrics, The Sahlgrenska Academy, the University of Gothenburg and Queen Silvia Children's Hospital, 41650 Gothenburg, Sweden.ORCID 0000-0002-9637-3439
Reiko HorikawaDivision of Endocrinology and Metabolism, National Center for Child Health and Development, 578535 Tokyo, Japan.ORCID 0000-0003-3429-3246
Veronica MericqInstitute of Maternal and Child Research, Faculty of Medicine, University of Chile, 8320000 Santiago de Chili, Chili.ORCID 0000-0003-2287-0181
Robert RapaportIcahn School of Medicine, Division of Pediatric Endocrinology, Mount Sinai Kravis Children's Hospital, New York, NY 10029, USA.ORCID 0000-0002-0915-3551
Abdullah AlherbishMedical Division, Al Habib Medical Group, Riyadh 12214, Saudi Arabia.
Debora BraslavskyCentro de Investigaciones Endocrinológicas "Dr. Cesar Bergadá" (CEDIE), División de Endocrinología, Hospital de Niños Dr. Ricardo Gutiérrez, C1425 Buenos Aires, Argentina.
Evangelia CharmandariDivision of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, National and Kapodistrian University of Athens Medical School, 'Aghia Sophia' Children's Hospital, 11527 Athens, Greece.
Steven D ChernausekDepartment of Pediatrics, Section of Diabetes and Endocrinology, University of Oklahoma Health Sciences Center, OK 73104 Oklahoma City, USA.
Wayne S CutfieldDivision of Pediatric Endocrinology, Liggins Institute, University of Auckland, Auckland 1142, New Zealand.
Andrew DauberDivision of Endocrinology, Children's National Hospital, Washington, DC 20012, USA.ORCID 0000-0003-4890-0262
Asma DeebPaediatric Endocrine Division, Sheikh Shakhbout Medical City and College of Medicine and Health Sciences, Khalifa University, Abu Dhabi, United Arab Emirates.
Wesley J GoedegebuureDepartment of Pediatrics, Subdivision of Endocrinology, Erasmus University Medical Center, 3015 CN Rotterdam, The Netherlands.
Paul L HofmanDivision of Pediatric Endocrinology, Liggins Institute, University of Auckland, Auckland 1142, New Zealand.
Elvira IsganatisJoslin Diabetes Center, Harvard Medical School, Boston, MA, USA.
Alexander A JorgeUnidade de Endocrinologia Genética (LIM25) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Christina Kanaka-GantenbeinDivision of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, National and Kapodistrian University of Athens Medical School, 'Aghia Sophia' Children's Hospital, 11527 Athens, Greece.ORCID 0000-0002-6963-5464
Kenichi KashimadaDepartment of Pediatrics and Developmental Biology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.
Vaman KhadilkarDepartment of Pediatrics, Jehangir Hospital, Pune, India.
Xiao-Ping LuoDepartment of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Sarah MathaiDepartment of Pediatrics, Christian Medical College, Vellore, India.
Yuya NakanoDepartment of Pediatrics, Showa University School of Medicine, Tokyo, Japan.
Mabel YauIcahn School of Medicine, Division of Pediatric Endocrinology, Mount Sinai Kravis Children's Hospital, New York, NY 10029, USA.
Erasmus MC · NLNational and Kapodistrian University of Athens · GRUniversity of Auckland · NZChildren's National · USChristian Medical College, Vellore · INHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BRHospital General de Niños Ricardo Gutierrez · ARJehangir Hospital · INJoslin Diabetes Center · USKhalifa University of Science and Technology · AENational Center For Child Health and Development · JPShowa University · JPTokyo Medical and Dental University · JPTongji Hospital · CNUniversidade Federal do Paraná · BRUniversity of Chile · CLUniversity of Gothenburg · SEUniversity of Oklahoma Health Sciences Center · USUniversity of Rome Tor Vergata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This International Consensus Guideline was developed by experts in the field of small for gestational age (SGA) of 10 pediatric endocrine societies worldwide. A consensus meeting was held and 1300 articles formed the basis for discussions. All experts voted about the strengths of the recommendations. The guideline gives new and clinically relevant insights into the etiology of short stature after SGA birth, including novel knowledge about (epi)genetic causes. Further, it presents long-term consequences of SGA birth and also reviews new treatment options, including treatment with gonadotropin-releasing hormone agonist (GnRHa) in addition to growth hormone (GH) treatment, as well as the metabolic and cardiovascular health of young adults born SGA after cessation of childhood GH treatment in comparison with appropriate control groups. To diagnose SGA, accurate anthropometry and use of national growth charts are recommended. Follow-up in early life is warranted and neurodevelopment evaluation in those at risk. Excessive postnatal weight gain should be avoided, as this is associated with an unfavorable cardiometabolic health profile in adulthood. Children born SGA with persistent short stature < -2.5 SDS at age 2 years or < -2 SDS at 3 to 4 years of age, should be referred for diagnostic workup. In case of dysmorphic features, major malformations, microcephaly, developmental delay, intellectual disability, and/or signs of skeletal dysplasia, genetic testing should be considered. Treatment with 0.033 to 0.067 mg GH/kg/day is recommended in case of persistent short stature at age of 3 to 4 years. Adding GnRHa treatment could be considered when short adult height is expected at pubertal onset. All young adults born SGA require counseling to adopt a healthy lifestyle.

Indexed as

Body HeightHuman Growth HormoneChildChild, PreschoolGestational AgeGrowth HormoneHumansInfantInfant, NewbornInfant, Small for Gestational AgeYoung AdultGrowth HormoneHuman Growth HormoneconsequencesetiologygeneticsGHmanagementSGA

Identifiers

PMID36635911
PMCPMC10166266
OpenAlexW4315797449

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.