ArticleClinical and experimental pediatrics2023
Pathogenetic and etiologic considerations of febrile seizures.
Article in Clinical and experimental pediatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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15 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- The Genotypic and Phenotypic Spectrum of GOSR2 Mutations: Clinical and Pathophysiological Insights.Journal of inherited metabolic disease · 2025Pooled it
- An interpretable machine learning model for predicting febrile seizures following enterovirus infection in children.Annals of medicine · 2026Article
- cGAS-mediated type I IFN signaling contributes to disease progression in drug-refractory epilepsy.Nature neuroscience · 2026Article
- Can epilepsy be predicted after the first febrile seizure? Insights from machine learning of postictal EEG.Epileptic disorders : international epilepsy journal with videotape · 2026Article
- Oral microbiota characteristics in children younger than 3 years with febrile seizures: a prospective observational study.BMC microbiology · 2026Observational
- Fever seizures beyond the typical age: clinical characteristics and subsequent epilepsy risks in children over five.Acta neurologica Belgica · 2026Review
- Association of respiratory viral detection with complex febrile seizures and hospitalisation in children after the COVID-19 pandemic: a retrospective observational study.BMJ paediatrics open · 2026Observational
- cGAS-mediated IFN-I signaling contributes to disease progression in drug-refractory epilepsy.bioRxiv : the preprint server for biology · 2026Article
- A Comprehensive Perspective on Febrile Seizures in Children: A Prospective Cohort Study with Evaluation of Clinical, Laboratory, and Genetic Features.Journal of clinical medicine · 2025Article
- BBB proteomic analysis reveals that complex febrile seizures in infancy enhance susceptibility to epilepsy in adulthood through dysregulation of ECM-receptor interaction signaling pathway.Fluids and barriers of the CNS · 2025Article
- Identification of Genetic Variants in Status Epilepticus Associated With Fever.Brain and behavior · 2025Observational
- Effect of environmental exposome and influenza infection on febrile seizure in children over 22 years: a time series analysis.International journal of biometeorology · 2024Article
- Article
- A preliminary study on the association between prognostic nutritional index and neutrophil-to-lymphocyte ratio with nutritional status and inflammation in febrile children's susceptibility to seizures.Revista da Associacao Medica Brasileira (1992) · 2024Observational
- [Clinical features of children with febrile seizures caused by Omicron variant infection].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2023Article
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2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Febrile seizure (FS), which occurs in febrile children without underlying health problems, is the most common type of seizure disorder in children. The suggested pathogenesis of FS derived from several animal and human studies is multifactorial and debatable. Neuronal hyperexcitability, which develops during inflammatory responses that accompany fever, provokes seizures. However, the exact role of each inflammatory mediator (e.g., cytokines) is undefined in terms of the connection between systemic or local inflammation and the central nervous system, and the mechanisms by which cytokines increase neuronal excitability remain unclear. In contrast, the cause of fever in most children with FS is usually mild respiratory virus infection (e.g., rhinovirus, influenza virus, adenovirus, and enterovirus) rather than severe bacterial infections. In temperate regions, the major causative respiratory viruses seem to mirror seasonally prevalent respiratory viruses in the community. Therefore, vigorous efforts to identify the causative pathogen of fever may not be necessary in children with FS. Genetic factors seem to play a role in neuronal hyperexcitability, and some types of genetic variation have been identified in several genes encoding ion channels of neurons that participate in neuronal excitation. Although most children with FS have benign outcomes, some characteristics such as complex FS, febrile status epilepticus, consecutive afebrile seizures, and the presence of neurodevelopmental disabilities may require further genetic and neurologic evaluations.
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