Evidence map›Paper›PMID 36635857›Full record

ArticleEuropace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology2023

Electrocardiographic findings in patients with arrhythmogenic cardiomyopathy and right bundle branch block ventricular tachycardia.

Mikael Laredo, Oholi Tovia-Brodie, Anat Milman, Yoav Michowitz, Rob W Roudijk, Giovanni Peretto, Nicolas Badenco, Anneline S J M Te Riele, Simone Sala, Guillaume Duthoit and 31 more

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In one paragraph

Article in Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Observational
  3. The diagnostic value of electrocardiogram in the left variants of desmosomal arrhythmogenic cardiomyopathy.European heart journal supplements : journal of the European Society of Cardiology · 2025
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  4. Article
  5. Review
  6. Catheter ablation of ventricular tachycardia in patients with arrhythmogenic right ventricular cardiomyopathy and biventricular involvement.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024
    Article
  7. Article
  8. Article
  9. Risk stratification of sudden cardiac death: a review.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023
    Review
  10. Electrocardiographic characteristics of right-bundle-branch-block premature ventricular complexes predicting absence of left ventricular scar in athletes with apparently structural normal heart.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

41 authors at 20 institutions in 10 countries.

Mikael LaredoInstitut de Cardiologie, Groupe Hospitalier Pitié-Salpêtrière, and Sorbonne Université, 47-83 boulevard de l'Hôpital, 75013, Paris, France.ORCID 0000-0002-7326-2656
Oholi Tovia-BrodieDepartment of Cardiology, Jesselson Integrated Heart Center, Shaare Zedek Medical Center, Jerusalem, Israel.
Anat MilmanLeviev Heart Institute, Sheba Medical Center, Tel-Hashomer and Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Yoav MichowitzDepartment of Cardiology, Jesselson Integrated Heart Center, Shaare Zedek Medical Center, Jerusalem, Israel.
Rob W RoudijkNetherlands Heart Institute, Utrecht, The Netherlands.
Giovanni PerettoIRCCS San Raffaele Scientific Institute, Milan, Italy.
Nicolas BadencoInstitut de Cardiologie, Groupe Hospitalier Pitié-Salpêtrière, and Sorbonne Université, 47-83 boulevard de l'Hôpital, 75013, Paris, France.
Anneline S J M Te RieleNetherlands Heart Institute, Utrecht, The Netherlands.
Simone SalaIRCCS San Raffaele Scientific Institute, Milan, Italy.
Guillaume DuthoitInstitut de Cardiologie, Groupe Hospitalier Pitié-Salpêtrière, and Sorbonne Université, 47-83 boulevard de l'Hôpital, 75013, Paris, France.
Elena ArbeloArrhythmia Section, Cardiology Department, Hospital Clínic, Universitat de Barcelona, and IDIBAPS, Institut d'Investigació August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
Sandro NinniUniversité de Lille et Institut Cœur-Poumon, CHRU Lille, Lille, France.
Alessio GasperettiDepartment of Cardiology, University Heart Center Zurich, Zurich, Switzerland.
J Peter van TintelenNetherlands Heart Institute, Utrecht, The Netherlands.
Gabriele PaglinoIRCCS San Raffaele Scientific Institute, Milan, Italy.
Xavier WaintraubInstitut de Cardiologie, Groupe Hospitalier Pitié-Salpêtrière, and Sorbonne Université, 47-83 boulevard de l'Hôpital, 75013, Paris, France.
Antoine AndorinService de Cardiologie, CHU de Nantes, Nantes, France.
Petr PeichlDepartment of Cardiology, Institute for Clinical and Experimental Medicine (IKEM), Prague, Czech Republic.
Laurens P BosmanNetherlands Heart Institute, Utrecht, The Netherlands.
Leonardo CaloDivision of Cardiology, Policlinico Casilino, Roma, Italy.
Carla GiustettoDivision of Cardiology, University of Torino, Department of Medical Sciences, Città della Salute e della Scienza Hospital, Torino, Italy.
Andrea RadinovicIRCCS San Raffaele Scientific Institute, Milan, Italy.
Paloma JordaArrhythmia Section, Cardiology Department, Hospital Clínic, Universitat de Barcelona, and IDIBAPS, Institut d'Investigació August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
Ruben Casado-ArroyoDepartment of Cardiology, Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium.
Esther ZorioCardiology Department at Hospital Universitario y Politecnico La Fe and Research Group on Inherited Heart Diseases, Sudden Death and Mechanisms of Disease (CaFaMuSMe) from the Instituto de Investigación Sanitaria (IIS) La Fe, Valencia, Spain.
Francisco J Bermúdez-JiménezCardiology Department, Hospital Universitario Virgen de las Nieves, Granada, Spain.
Elijah R BehrCardiovascular Sciences and Cardiology Clinical Academic Group St. George's University Hospitals NHS Foundation Trust, London, UK.
Stepan HavranekSecond Department of Medicine-Department of Cardiovascular Medicine, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic.
Jacob Tfelt-HansenThe Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, and Section of genetics, Department of Forensic Medicine, Faculty of Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Frederic SacherHôpital Cardiologique du Haut-Lévêque & Université Bordeaux, LIRYC Institute, Bordeaux, France.
Jean-Sylvain HermidaCentre Hospitalier Universitaire d'Amiens-Picardie, Amiens, France.
Eyal NofLeviev Heart Institute, Sheba Medical Center, Tel-Hashomer and Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Michela CasellaCardiology and Arrhythmology Clinic, Department of Clinical, Special and Dental Sciences, Marche Polytechnic University, Ancona, Italy.
Josef KautznerDepartment of Cardiology, Institute for Clinical and Experimental Medicine (IKEM), Prague, Czech Republic.
Dominique LacroixUniversité de Lille et Institut Cœur-Poumon, CHRU Lille, Lille, France.
Josep BrugadaArrhythmia Section, Cardiology Department, Hospital Clínic, Universitat de Barcelona, and IDIBAPS, Institut d'Investigació August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
Firat DuruDepartment of Cardiology, University Heart Center Zurich, Zurich, Switzerland.
Paolo Della BellaIRCCS San Raffaele Scientific Institute, Milan, Italy.
Estelle GandjbakhchInstitut de Cardiologie, Groupe Hospitalier Pitié-Salpêtrière, and Sorbonne Université, 47-83 boulevard de l'Hôpital, 75013, Paris, France.
Richard HauerNetherlands Heart Institute, Utrecht, The Netherlands.
Bernard BelhassenHeart Institute, Hadassah University Hospital, Jerusalem and Sackler School of Medicine, Tel-Aviv University, Kyriat Hadassah, PO Box 12000, 91120, Jerusalem, Israel.
Sorbonne Université · FRVita-Salute San Raffaele University · ITUniversity Medical Center Utrecht · NLConsorci Institut D'Investigacions Biomediques August Pi I Sunyer · ESTel Aviv University · ILInstitute of Clinical and Experimental Medicine · CZShaare Zedek Medical Center · ILUniversité de Lille · FRZurich Heart House · CHCentre Hospitalier Universitaire Amiens-Picardie · FRCentre Hospitalier Universitaire de Nantes · FRCentro de Investigación en Red en Enfermedades Cardiovasculares · ESCharles University · CZElectrophysiology and Heart Modeling Institute · FRHospital Universitario Virgen de las Nieves · ESMarche Polytechnic University · ITNetherlands Heart Institute · NLPoliclinico Casilino · ITSt George’s University Hospitals NHS Foundation Trust · GBUniversité Libre de Bruxelles · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsLittle is known about patients with right bundle branch block (RBBB)-ventricular tachycardia (VT) and arrhythmogenic cardiomyopathy (ACM). Our aims were: (i) to describe electrocardiogram (ECG) characteristics of sinus rhythm (SR) and VT; (ii) to correlate SR with RBBB-VT ECGs; and (iii) to compare VT ECGs with electro-anatomic mapping (EAM) data. METHODS AND

resultsFrom the European Survey on ACM, 70 patients with spontaneous RBBB-VT were included. Putative left ventricular (LV) sites of origin (SOOs) were estimated with a VT-axis-derived methodology and confirmed by EAM data when available. Overall, 49 (70%) patients met definite Task Force Criteria. Low QRS voltage predominated in lateral leads (n = 37, 55%), but QRS fragmentation was more frequent in inferior leads (n = 15, 23%). T-wave inversion (TWI) was equally frequent in inferior (n = 28, 42%) and lateral (n = 27, 40%) leads. TWI in inferior leads was associated with reduced LV ejection fraction (LVEF; 46 ± 10 vs. 53 ± 8, P = 0.02). Regarding SOOs, the inferior wall harboured 31 (46%) SOOs, followed by the lateral wall (n = 17, 25%), the anterior wall (n = 15, 22%), and the septum (n = 4, 6%). EAM data were available for 16 patients and showed good concordance with the putative SOOs. In all patients with superior-axis RBBB-VT who underwent endo-epicardial VT activation mapping, VT originated from the LV.

conclusionsIn patients with ACM and RBBB-VT, RBBB-VTs originated mainly from the inferior and lateral LV walls. SR depolarization and repolarization abnormalities were frequent and associated with underlying variants.

Indexed as

CardiomyopathiesTachycardia, VentricularBundle-Branch BlockElectrocardiographyHeart VentriclesHumansArrhythmogenic cardiomyopathyArrhythmogenic right ventricular cardiomyopathyECGSite of originVentricular arrhythmia

Identifiers

PMID36635857
PMCPMC10062349
OpenAlexW4315782560

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.