Evidence map›Paper›PMID 36635660›Full record

Trial reportMalaria journal2023

Durable wall lining for malaria control in Liberia: results of a cluster randomized trial.

David Giesbrecht, Tuwuyor G Belleh, Julie Pontarollo, Victor S Hinneh, Oliver Pratt, Sajid Kamal, Richard Allan

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Malaria journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02448745 (Liberia Insecticide Treated Durable Wall Linings Study), which is not on this map. Cited by 3 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02448745 nacompletednot on this map

Liberia Insecticide Treated Durable Wall Linings Study: Protocol for a Cluster Randomised Trial (DL)

TypeinterventionalSponsorThe Mentor InitiativeRan2014 to 2017Enrolled6,317ConditionsMalaria, Falciparum, AnemiaArmsInsecticide treated wall lining
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

David GiesbrechtDepartment of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA.
Tuwuyor G BellehABT Associates, Monrovia, Liberia.
Julie PontarolloThe MENTOR Initiative, Haywards Heath, UK.
Victor S HinnehLiberia National Malaria Control Programme, Monrovia, Liberia.
Oliver PrattLiberia National Malaria Control Programme, Monrovia, Liberia.
Sajid KamalThe MENTOR Initiative, Haywards Heath, UK.
Richard AllanThe MENTOR Initiative, Haywards Heath, UK. Richard.allan@mentor-initiative.net.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMalaria control in Liberia depends upon universal coverage with pyrethroid-impregnated long-lasting insecticidal nets (LLINs). Despite regular mass distribution, LLIN coverage and usage is patchy. Pyrethroid resistance in malaria vectors may further reduce LLIN efficacy. Durable Wall Lining (DWL), a novel material treated with two non-pyrethroid class insecticides, was designed to be installed onto the surface of inner walls, and cover openings and ceiling surfaces of rural houses.

objectives

aimTo determine the malaria control efficacy of DWL. PRIMARY

objectiveTo determine if DWL has an additional protective effect in an area of pyrethroid resistance. SECONDARY

objectivesTo compare surface bio-availability of insecticides and entomological effectiveness over the study duration.

designA cluster randomized trial.

participantsChildren aged 2-59 months. CONTROL ARM: 50 houses per 20 clusters, all of which received LLIN within the previous 12 months. ACTIVE ARM: 50 houses per 20 experimental clusters, all of which received LLINs with the previous 12 months, and had internal walls and ceilings lined with DWL. RANDOMISATION: Cluster villages were randomly allocated to control or active arms, and paired on 4 covariates.

main outcome measuresPRIMARY MEASURE: Prevalence of infection with P. falciparum in children aged 2 to 59 months. SECONDARY MEASURE: Surface bioavailability and entomological effectiveness of DWL active ingredients.

resultsPlasmodium falciparum prevalence in active clusters after 12 months was 34.6% compared to 40.1% in control clusters (p = 0.052). The effect varied with elevation and was significant (RR = 1.3, p = 0.022) in 14 pairs of upland villages. It was not significant (RR = 1.3, p = 0.344) in 6 pairs of coastal villages. Pooled risk ratio (RR) was calculated in SAS (Cary, NC, USA) using the Cochran-Mantel-Haenszel (CMH) test for upland and coastal cluster pairs. DWL efficacy was sustained at almost 100% for 12 months.

conclusionsFindings indicate that DWL is a scalable and effective malaria control intervention in stable transmission areas with pyrethroid-resistant vectors, where LLIN usage is difficult to achieve, and where local housing designs include large gable and eve openings. Trial registration ClinicalTrials.gov identifier: NCT02448745 (19 May 2015): https://clinicaltrials.gov/ct2/show/NCT02448745.

Indexed as

InsecticidesInsecticide-Treated BednetsMalariaMalaria, FalciparumPyrethrinsChildHumansLiberiaMosquito ControlInsecticidesPyrethrinsDurable wall liningLLINsMalariaRural housingVectors

Identifiers

PMID36635660
PMCPMC9837910

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.