Evidence map›Paper›PMID 36635648›Full record

Observational studyBMC cardiovascular disorders2023

Characterisation of patients referred to a tertiary-level inherited cardiac condition clinic with suspected arrhythmogenic right ventricular cardiomyopathy (ARVC).

A Aljehani, T Kew, S Baig, H Cox, L C Sommerfeld, B Ensam, M Kalla, R P Steeds, L Fabritz

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC cardiovascular disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

A AljehaniInstitute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK. AXA1388@student.bham.ac.uk.
T KewInstitute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK.
S BaigInstitute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK.
H CoxWest Midlands Regional Genetics Unit, Clinical Genetics, Birmingham Women's and Children's NHS Foundation Trust (BWC) Birmingham, Birmingham, UK.
L C SommerfeldInstitute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK.
B EnsamDepartment of Cardiology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
M KallaInstitute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK.
R P SteedsInstitute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK.
L FabritzInstitute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK.
University of Birmingham · GBUniversity Hospitals Birmingham NHS Foundation Trust · GBBirmingham Women’s and Children’s NHS Foundation Trust · GBKing Saud bin Abdulaziz University for Health Sciences · SAUniversity Medical Center Hamburg-Eppendorf · DE

Funding

British Heart Foundation AA/18/2/34218EU Horizon 2020 MAESTRIA 965286Medical Research Council
6 · The paper itself

Abstract

backgroundArrhythmogenic right ventricular cardiomyopathy (ARVC) or arrhythmogenic cardiomyopathy is a rare inherited disease with incomplete penetrance and an environmental component. Although a rare disease, ARVC is a common cause of sudden cardiac death in young adults. Data on the different stages of ARVC remains scarce. The purpose of this study is to describe the initial presentation and cardiac phenotype of definite and non-definite ARVC for patients seen at a tertiary service.

methodsThis is a single centre, observational cohort study of patients with definite and non-definite ARVC seen at the Inherited Cardiac Conditions services at University Hospital Birmingham (UHB) in the period 2010-2021. Patients were identified by interrogation of digital health records, medical history, imaging and by examining 12-lead electrocardiograms (ECG).

resultThe records of 1451 patients were reviewed; of those, 165 patients were at risk of ARVC (mean age 41 ± 17 years, 56% male). 60 patients fulfilled task force criteria for definite ARVC diagnosis (n = 40, 67% males), and 38 (72%) of them carried a known pathogenic variant. The remaining 105 patients (50% males) were non-definite, and of these 45 (62%) carried a known pathogenic variant. Patients in the definite group were more symptomatic, with palpitations (57% vs. 17%), syncope (35% vs. 6%) and shortness of breath (28% vs. 5%, p < 0.001). T-wave inversion in V1-V3 and epsilon waves were observed only in the definite group. Both PR interval and QRS duration were longer in the definite (170 ± 34 ms and 100 ± 19 ms, p < 0.001) compared to (149 ± 25 and 91 ± 14 ms, p = 0.005). Patients with definite ARVC had significantly larger RV end diastolic areas and significantly reduced biventricular function (RVEDA = 27 ± 10 cm

conclusionOur study showed differences between definite and non-definite ARVC patients in terms of clinical, electrophysiological and imaging features. Major adverse cardiac events occurred more commonly in the definite group, but also were observed in non-definite ARVC. This single centre observational cohort study forms a basis for further prospective multicentre interventional studies.

Indexed as

Arrhythmogenic Right Ventricular DysplasiaTachycardia, VentricularArrhythmias, CardiacCohort StudiesElectrocardiographyFemaleHumansMaleArrhythmogenic cardiomyopathyArrhythmogenic right ventricular cardiomyopathyCardiac magnetic resonance imagingEchocardiographyElectrocardiography

Identifiers

PMID36635648
PMCPMC9837886
OpenAlexW4315707331

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.