ArticleThe ISME journal2023
Bacterial volatile organic compounds attenuate pathogen virulence via evolutionary trade-offs.
Article in The ISME journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Principles for Rigorous Design and Application of Synthetic Microbial Communities.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Pooled it
- Bacteria-phage coevolution drives variation in bacterial wilt disease incidence via resistance-virulence trade-offs.Nature microbiology · 2026Article
- Competition between resident rhizosphere bacteria enhances phytopathogen suppression via emergent antagonism.The ISME journal · 2026Article
- Article
- Exploring Fungal Communication Mechanisms in the Rhizosphere Microbiome for a Sustainable Green Agriculture.Journal of fungi (Basel, Switzerland) · 2025Review
- The Role of Plant Growth-Promoting Bacteria in Soil Restoration: A Strategy to Promote Agricultural Sustainability.Microorganisms · 2025Review
- Development of a chemotactic SynCom bioorganic fertilizer for biocontrol of bacterial wilt in tobacco fields.Applied microbiology and biotechnology · 2025Article
- Exploring the temporal dynamics of a disease suppressive rhizo-microbiome in eggplants.iScience · 2024Article
- Root volatiles manipulate bacterial biofilms.Nature ecology & evolution · 2024Article
- Phage selection drives resistance-virulence trade-offs inEvolution letters · 2024Article
- Protist predation selects for the soil resistome.The ISME journal · 2024Article
- A Plasmid-Borne Gene Cluster Flanked by Two Restriction-Modification Systems Enables an Arctic Strain ofInternational journal of molecular sciences · 2023Article
- Microbial volatiles mediate bacterial evolutionary dynamics.The ISME journal · 2023Article
- Co-evolution within the plant holobiont drives host performance.EMBO reports · 2023Review
- Plant and soil-associated microbiome dynamics determine the fate of bacterial wilt pathogen Ralstonia solanacearum.Planta · 2023Review
- Microbial Consortia for Plant Protection against Diseases: More than the Sum of Its Parts.International journal of molecular sciences · 2023Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 4 countries.
Funding
Abstract
Volatile organic compounds (VOCs) produced by soil bacteria have been shown to exert plant pathogen biocontrol potential owing to their strong antimicrobial activity. While the impact of VOCs on soil microbial ecology is well established, their effect on plant pathogen evolution is yet poorly understood. Here we experimentally investigated how plant-pathogenic Ralstonia solanacearum bacterium adapts to VOC-mixture produced by a biocontrol Bacillus amyloliquefaciens T-5 bacterium and how these adaptations might affect its virulence. We found that VOC selection led to a clear increase in VOC-tolerance, which was accompanied with cross-tolerance to several antibiotics commonly produced by soil bacteria. The increasing VOC-tolerance led to trade-offs with R. solanacearum virulence, resulting in almost complete loss of pathogenicity in planta. At the genetic level, these phenotypic changes were associated with parallel mutations in genes encoding lipopolysaccharide O-antigen (wecA) and type-4 pilus biosynthesis (pilM), which both have been linked with outer membrane permeability to antimicrobials and plant pathogen virulence. Reverse genetic engineering revealed that both mutations were important, with pilM having a relatively larger negative effect on the virulence, while wecA having a relatively larger effect on increased antimicrobial tolerance. Together, our results suggest that microbial VOCs are important drivers of bacterial evolution and could potentially be used in biocontrol to select for less virulent pathogens via evolutionary trade-offs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.