Evidence map›Paper›PMID 36635220›Full record

ArticleCerebral cortex (New York, N.Y. : 1991)2023

Quantitative morphometric changes in vascular mild cognitive impairment patients: early diagnosis of dementia.

Jitian Guan, Qiuyu Li, Zhuozhi Dai, Lingfeng Lai, Shuyi Sun, Yiqun Geng, Zhiwei Shen, Lan Luo, Yanlong Jia, Lin Yang and 3 more

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In one paragraph

Article in Cerebral cortex (New York, N.Y. : 1991), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Jitian GuanDepartment of Radiology, The 2nd Affiliated Hospital, Medical College of Shantou University, Shantou 515041, China.
Qiuyu LiDepartment of Radiology, The 2nd Affiliated Hospital, Medical College of Shantou University, Shantou 515041, China.
Zhuozhi DaiDepartment of Radiology, The 2nd Affiliated Hospital, Medical College of Shantou University, Shantou 515041, China.
Lingfeng LaiDepartment of Radiology, The 2nd Affiliated Hospital, Medical College of Shantou University, Shantou 515041, China.ORCID 0000-0002-7645-4493
Shuyi SunDepartment of Radiology, The 2nd Affiliated Hospital, Medical College of Shantou University, Shantou 515041, China.
Yiqun GengLaboratory of Molecular Pathology, Shantou University Medical College, Shantou 515041, China.
Zhiwei ShenDepartment of Radiology, The 2nd Affiliated Hospital, Medical College of Shantou University, Shantou 515041, China.
Lan LuoDepartment of Radiology, The 2nd Affiliated Hospital, Medical College of Shantou University, Shantou 515041, China.ORCID 0000-0002-6443-4305
Yanlong JiaDepartment of Radiology, The 2nd Affiliated Hospital, Medical College of Shantou University, Shantou 515041, China.
Lin YangDepartment of Radiology, The 2nd Affiliated Hospital, Medical College of Shantou University, Shantou 515041, China.
Yanyan TangDepartment of Radiology, The 2nd Affiliated Hospital, Medical College of Shantou University, Shantou 515041, China.
Gen YanDepartment of Radiology, The Second Affiliated Hospital of Xiamen Medical College, Xiamen 515041, China.
Renhua WuDepartment of Radiology, The 2nd Affiliated Hospital, Medical College of Shantou University, Shantou 515041, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vascular mild cognitive impairment (VMCI) is an early and reversible stage of dementia. Volume differences in regional gray matter may reveal the development and prognosis of VMCI. This study selected 2 of the most common types of VMCI, namely, periventricular white matter hyperintensities (PWMH, n = 14) and strategic single infarctions (SSI, n = 10), and used the voxel-based morphometry method to quantify their morphological characteristics. Meanwhile, age- and sex-matched healthy volunteers were included (n = 16). All the participants were neuropsychologically tested to characterize their cognitive function and underwent whole-brain magnetic resonance imaging scanning. Our results showed that the volumes of the bilateral temporal lobes and bilateral frontal gray matter were obviously diminished in the PWMH group. The atrophy volume difference was 4,086 voxels in the left temporal lobe, 4,154 voxels in the right temporal lobe, 1,718 voxels in the left frontal lobe, and 1,141 voxels in the right frontal lobe (P ≤ 0.001). Moreover, the characteristics of the gray matter atrophy associated with the PWMH were more similar to those associated with Alzheimer's disease than SSI, which further revealed the susceptibility for escalation from PWMH to dementia. In conclusion, PWMH patients and SSI patients have different morphological characteristics, which explain the different prognoses of VMCI.

Indexed as

Alzheimer DiseaseCognitive DysfunctionAtrophyBrainEarly DiagnosisGray MatterHumansMagnetic Resonance ImagingNeuropsychological Testsatrophymagnetic resonance imagingtemporal lobevascular mild cognitive impairmentvoxel-based morphometry

Identifiers

PMID36635220
PMCPMC10152087

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