Evidence map›Paper›PMID 36635157›Full record

ArticleAnais brasileiros de dermatologia

Quantification of human polyomaviruses MCPyV and HPyV6 in malignant and non-malignant skin lesions.

Marianna T Venceslau, Gabriella R M da Costa, Maria Angelica A M Guimarães, Rafael B Varella, Flavio B Luz

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Anais brasileiros de dermatologia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Marianna T VenceslauDepartment of Preventive Medicine, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil. Electronic address: venceslaumarianna@gmail.com.
Gabriella R M da CostaDepartment of Preventive Medicine, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Maria Angelica A M GuimarãesDepartment of Preventive Medicine, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Rafael B VarellaDepartment of Microbiology and Parasitology, Biomedical Institute, Universidade Federal Fluminense, Niteroi, RJ,Brazil.
Flavio B LuzDepartment of Clinical Medicine, Sector of Dermatology, Hospital Universitário Antônio Pedro, Universidade Federal Fluminense, Niteroi, RJ, Brazil.
Universidade Federal do Rio de Janeiro · BRUniversidade Federal Fluminense · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHuman Polyomaviruses such as MCPyV and HPyV6 are frequently found as part of healthy skin microbiota and have been associated with Merkel cell carcinoma (MCC), pruritic and dyskeratotic dermatoses, respectively. Their presence in other types of skin conditions varies greatly depending on lesion type and population.

objectiveTo analyse comparatively the presence of MCPyV and HPyV6 in nonmelanoma skin cancers and healthy skin.

methodsThe authors utilized qPCR techniques to quantify these pathogens in NMSC, premalignant diseases, and healthy skin of 87 patients.

resultsMCPyV was detected in over 40% of samples, while HPyV6 was in 9.6%. MCPyV load was higher in squamous cell carcinomas (SCC) compared to basal cell carcinomas (BCC) (p=0.016) and HPyV6 showed a higher percentage of infected cells in areas of low solar exposure as well as normal skin (p=0.012). A fair agreement (kappa=0.301) was found between MCPyV detection in lesions and their respective perilesional skin, indicating a random process of local dissemination of the virus. STUDY LIMITATIONS: The lack of a larger sampling of different lesion types and protein expression analyses limits the correlation findings.

conclusionThis is the first report of HPyV6 detection in the healthy skin of a Brazilian population, but the role of both polyomaviruses in NMSC has yet to be demonstrated.

Indexed as

Basal Cell CarcinomaCarcinoma, Merkel CellMerkel cell polyomavirusPolyomavirusSkin NeoplasmsDNA, ViralHumansDNA, ViralCarcinogenesisMerkel cell polyomavirusPolyomavirusSkin neoplasmsVirus diseases

Identifiers

PMID36635157
PMCPMC9984872
OpenAlexW4313910066

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.