Evidence map›Paper›PMID 36635147›Full record

ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2023

Aberrant Emotional Prosody Circuitry Predicts Social Communication Impairments in Children With Autism.

Simon Leipold, Daniel A Abrams, Shelby Karraker, Jennifer M Phillips, Vinod Menon

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Simon LeipoldDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California. Electronic address: simon.leipold@donders.ru.nl.
Daniel A AbramsDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California.
Shelby KarrakerDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California.
Jennifer M PhillipsDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California.
Vinod MenonDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California; Department of Neurology and Neurological Sciences, Stanford University, Stanford, California; Stanford Neurosciences Institute, Stanford University, Stanford, California. Electronic address: menon@stanford.edu.
Stanford University · USNeurosciences Institute · US

Funding

Mathematical Cognition in Autism: A Cognitive and Systems Neuroscience ApproachR01MH084164 · NIMH · STANFORD UNIVERSITY · PI MENON, VINOD · 2011 to 2021
$6.7M
Speaker-listener coupling and brain dynamics during naturalistic verbal communication in children with autismR21DC017950 · NIDCD · STANFORD UNIVERSITY · PI ABRAMS, DANIEL ARTHUR, MENON, VINOD · 2020 to 2021
$827k
Decoding Neural Systems Underlying Affective Prosody in Children with AutismK01MH102428 · NIMH · STANFORD UNIVERSITY · PI ABRAMS, DANIEL ARTHUR · 2014 to 2016
$525k
NIDCD NIH HHS R21 DC017950NIMH NIH HHS K01 MH102428NIMH NIH HHS R01 MH084164
6 · The paper itself

Abstract

backgroundEmotional prosody provides acoustical cues that reflect a communication partner's emotional state and is crucial for successful social interactions. Many children with autism have deficits in recognizing emotions from voices; however, the neural basis for these impairments is unknown. We examined brain circuit features underlying emotional prosody processing deficits and their relationship to clinical symptoms of autism.

methodsWe used an event-related functional magnetic resonance imaging task to measure neural activity and connectivity during processing of sad and happy emotional prosody and neutral speech in 22 children with autism and 21 matched control children (7-12 years old). We employed functional connectivity analyses to test competing theoretical accounts that attribute emotional prosody impairments to either sensory processing deficits in auditory cortex or theory of mind deficits instantiated in the temporoparietal junction (TPJ).

resultsChildren with autism showed specific behavioral impairments for recognizing emotions from voices. They also showed aberrant functional connectivity between voice-sensitive auditory cortex and the bilateral TPJ during emotional prosody processing. Neural activity in the bilateral TPJ during processing of both sad and happy emotional prosody stimuli was associated with social communication impairments in children with autism. In contrast, activity and decoding of emotional prosody in auditory cortex was comparable between autism and control groups and did not predict social communication impairments.

conclusionsOur findings support a social-cognitive deficit model of autism by identifying a role for TPJ dysfunction during emotional prosody processing. Our study underscores the importance of tuning in to vocal-emotional cues for building social connections in children with autism.

Indexed as

Autistic DisorderSpeech PerceptionChildCommunicationEmotionsHumansSpeechAutism spectrum disorderEmotion recognitionSocial cognitionTPJVoice

Identifiers

PMID36635147
PMCPMC10973204
OpenAlexW4304893338

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.