ArticleClinical endoscopy2023
Endoscopic submucosal dissection for superficial esophageal squamous cell carcinoma: long-term follow-up in a Western center.
Article in Clinical endoscopy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Endoscopic resection of early esophageal neoplasia in patients with esophageal varices: a systematic review.Endoscopy · 2025Pooled it
- Endoscopic submucosal dissection in early esophageal neoplasia: Celebrating efficacy, confronting heterogeneity, and refining surveillance for high-risk patients.World journal of clinical oncology · 2026Article
- Endoscopic submucosal dissection for early gastrointestinal malignancies: Current state and future perspectives.World journal of gastrointestinal endoscopy · 2025Review
- Feasibility and predictors of same-day discharge following endoscopic submucosal dissection for early esophageal cancer.BMC gastroenterology · 2025Article
- Navigating the Treatment Landscape for Widespread Superficial Esophageal Squamous Cell Neoplasia.Gut and liver · 2025Article
- Non-Curative Endoscopic Submucosal Dissection: Current Concepts, Pitfalls and Future Perspectives.Journal of clinical medicine · 2025Review
- Long-Term Outcomes of Esophageal Squamous Neoplasia with Muscularis Mucosa Involvement after Endoscopic Submucosal Dissection.Biomedicines · 2024Article
- Endoscopic submucosal dissection for early esophageal squamous cell carcinoma: long-term results from a Western cohort.Endoscopy · 2024Article
- Endoscopic Submucosal Dissection for Esophageal Cancer: Current and Future.Life (Basel, Switzerland) · 2023Review
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsEndoscopic submucosal dissection (ESD) has been established as a treatment modality for superficial esophageal squamous cell carcinoma (ESCC). Long-term follow-up data are lacking in Western countries. The aim of this study was to analyze long-term survival in a Western center.
methodsPatients undergoing ESD for ESCC were included. The analysis was performed retrospectively using a prospectively collected database.
resultsR0 resection rate was 96.7% (59/61 lesions in 58 patients). Twenty-seven patients (46.6%) fulfilled the curative resection criteria (M1/M2) (group A), 11 patients (19.0%) had M3 lesions without lymphovascular invasion (LVI) (group B), and 20 patients (34.5%) had lesions with submucosal invasion or LVI (group C). Additional treatment was recommended after non-curative resection. It was not performed in 20/31 patients (64.5%), mainly because of comorbidities (75%). Twenty-nine out of 58 (50.0%) patients died during a mean follow-up of 3.7 years. Death was related to ESCC in 17.2% (5/29) of patients. The disease-specific survival rate after curative resection was 100%. Overall survival rates after 5 years were 61.5%, 63.6% and 28.1% for groups A, B, and C, respectively. The overall survival was significantly worse after non-curative resection (p=0.038).
conclusionNon-curative resection is frequent after ESD for ESCC in Western patients. The long-term prognosis is limited and mainly determined by comorbidity. Early diagnosis and pre-interventional assessments need to be improved.
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