Evidence map›Paper›PMID 36634637›Full record

ArticleFetal diagnosis and therapy2022

In vivo Sealing of Fetoscopy-Induced Fetal Membrane Defects by Mussel Glue.

Eva Avilla-Royo, Frauke Seehusen, Yannick R Devaud, Josep M Monné Rodriguez, Nele Strübing, Miriam Weisskopf, Phillip B Messersmith, Ladina Vonzun, Ueli Moehrlen, Martin Ehrbar and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Fetal diagnosis and therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Eva Avilla-RoyoDepartment of Obstetrics, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Frauke SeehusenLaboratory for Animal Model Pathology, Institute of Veterinary Pathology, University of Zurich, Zurich, Switzerland.
Yannick R DevaudDepartment of Obstetrics, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Josep M Monné RodriguezLaboratory for Animal Model Pathology, Institute of Veterinary Pathology, University of Zurich, Zurich, Switzerland.
Nele StrübingDepartment of Obstetrics, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Miriam WeisskopfCenter of Surgical Research, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Phillip B MessersmithDepartments of Bioengineering and Materials Science and Engineering, University of California, Berkeley, California, USA.
Ladina VonzunDepartment of Obstetrics, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Ueli MoehrlenThe Zurich Center for Fetal Diagnosis and Therapy, Zurich, Switzerland.
Martin EhrbarDepartment of Obstetrics, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Nicole Ochsenbein-KölbleDepartment of Obstetrics, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
University of Zurich · CHUniversity of California, Berkeley · US

Funding

Bioinspired Polymers for Fetal Membrane Pre-SealingR01EB022031 · NIBIB · UNIVERSITY OF CALIFORNIA BERKELEY · PI MESSERSMITH, PHILLIP B · 2016 to 2019
$1.3M
NIBIB NIH HHS R01 EB022031
6 · The paper itself

Abstract

introductionThe benefits of fetal surgery are impaired by the high incidence of iatrogenic preterm prelabor rupture of the fetal membranes (iPPROM), for which chorioamniotic separation has been suggested as a potential initiator. Despite the urgent need to prevent iPPROM by sealing the fetoscopic puncture site after intervention, no approach has been clinically translated.

methodsA mussel-inspired biomimetic glue was tested in an ovine fetal membrane (FM) defect model. The gelation time of mussel glue (MG) was first optimized to make it technically compatible with fetal surgery. Then, the biomaterial was loaded in polytetrafluoroethylene-coated nitinol umbrella-shaped receptors and applied on ovine FM defects (N = 10) created with a 10 French trocar. Its sealing performance and tissue response were analyzed 10 days after implantation by amniotic fluid (AF) leakage and histological methods.

resultsAll ewes and fetuses recovered well after the surgery, and 100% ewe survival and 91% fetal survival were observed at explantation. All implants were tight at explantation, and no AF leakage was observed in any of them. Histological analysis revealed a mild tissue response to the implanted glue.

conclusionMG showed promising properties for the sealing of FM defects and thereby the prevention of preterm birth. Studies to analyze the long-term tissue response to the sealant should be performed.

Indexed as

Premature BirthPremature Rupture of Fetal MembranesAnimalsExtraembryonic MembranesFemaleFetoscopyFetusHumansInfant, NewbornPregnancySheepFetal membranesFetoscopyIatrogenic preterm prelabor rupture of the fetal membranesIn vivo sealingMussel glue

Identifiers

PMID36634637
PMCPMC10015749
OpenAlexW4315783540

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.