Evidence map›Paper›PMID 36634460›Full record

ArticleJournal of autoimmunity2023

Pre-existing conditions associated with post-acute sequelae of COVID-19.

Elizabeth T Jacobs, Collin J Catalfamo, Paulina M Colombo, Sana M Khan, Erika Austhof, Felina Cordova-Marks, Kacey C Ernst, Leslie V Farland, Kristen Pogreba-Brown

Abstract read
In one paragraph

Article in Journal of autoimmunity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  11. Long-COVID symptom burden and the experience of adversity: the importance of response-shift effects over 3 years of the pandemic.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025
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  18. Long Covid Defined.The New England journal of medicine · 2024
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  19. The faces of Long-COVID: interplay of symptom burden with socioeconomic, behavioral and healthcare factors.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Elizabeth T JacobsMel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, USA. Electronic address: jacobse@email.arizona.edu.
Collin J CatalfamoMel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, USA.
Paulina M ColomboMel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, USA.
Sana M KhanMel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, USA.
Erika AusthofMel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, USA.
Felina Cordova-MarksMel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, USA.
Kacey C ErnstMel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, USA.
Leslie V FarlandMel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, USA.
Kristen Pogreba-BrownMel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Post-acute sequelae of COVID-19 (PASC) are conditions that occur or remain at least 28 days after SARS-CoV-2 infection. While some risk factors for PASC have been identified, little is known about pre-existing conditions that render one susceptible to developing PASC. Data from participants (n = 1224) in a longitudinal COVID-19 cohort study in Arizona were used to investigate comorbid conditions associated with PASC. After adjustment of the models for age, BMI, gender, race, and smoking, the following pre-existing conditions were statistically significantly associated with the development of PASC: asthma (OR = 1.54; 95% CI = 1.10-2.15); chronic constipation (OR = 4.29; 95% CI = 1.15-16.00); reflux (OR = 1.54; 95% CI = 1.01-2.34); rheumatoid arthritis (OR = 3.69; 95%CI = 1.15-11.82); seasonal allergies (OR = 1.56; 95% CI = 1.22-1.98); and depression/anxiety (OR = 1.72; 95% CI = 1.17-2.52). When grouping conditions together, statistically significant associations with PASC were observed for respiratory (OR = 1.47; 95% CI = 1.06-2.14); gastrointestinal (OR = 1.62; 95% CI = 1.16-2.26), and autoimmune conditions (OR = 4.38; 95% CI = 1.59-12.06). After adjustment for severity of acute SARS-CoV-2 infection and depression/anxiety, seasonal allergies (OR = 1.48; 95% CI 1.15-1.91) and autoimmune disease (OR = 3.78; 95% CI - 1.31-10.91) remained significantly associated with risk for PASC. These findings indicate that numerous pre-existing conditions may be associated with an increased risk for the development of PASC. Patients with these conditions should consider taking extra steps to avoid infection.

Indexed as

AsthmaAutoimmune DiseasesCOVID-19Cohort StudiesDisease ProgressionHumansPost-Acute COVID-19 SyndromePreexisting Condition CoverageSARS-CoV-2COVID-19PASCSARS-CoV-2

Identifiers

PMID36634460
PMCPMC9816074

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.