SynthesisPloS one2023
Social isolation as a risk factor for all-cause mortality: Systematic review and meta-analysis of cohort studies.
Synthesis in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Loneliness, social isolation, and living alone: a comprehensive systematic review, meta-analysis, and meta-regression of mortality risks in older adults.Aging clinical and experimental research · 2025Pooled it
- Access improvement in healthcare: a 12-step framework for operational practice.Frontiers in health services · 2024Pooled it
- Energy constraint on human health.Trends in endocrinology and metabolism: TEM · 2026Review
- Loneliness and social isolation as predictors of pain medication use transitions in older adults.Scientific reports · 2026Article
- Perceived Disease Burden and Social Support Among Adults on Hemodialysis in Northern Colombia: A Cross-Sectional Study.Nursing reports (Pavia, Italy) · 2026Article
- Development and validation of the Korea University Social Isolation Scale.BMC public health · 2026Article
- Personality Traits and Social Isolation in Older Adults.JAMA network open · 2026Article
- Social support and hospitalization in the elderly: investigating the role of frailty trajectories.European journal of public health · 2026Article
- Community as Medicine: A Qualitative Study of How Group Health Coaching and Social Connection Improve Mental Well-Being in Older Adults.Healthcare (Basel, Switzerland) · 2026Article
- Multidimensional Frailty and Mortality in Transcatheter Aortic Valve Implantation Patients - Prognostic Value of the Kihon Checklist.Circulation reports · 2026Article
- "I Could Practice Flirting Without Pressure": A Proof-of-Concept Study of an AI Chatbot-Assisted Intervention for Men Facing Distressing Involuntary Singlehood.Archives of sexual behavior · 2026Article
- Physical activity and loneliness interrelations with retirement status, health, and personality factors: a theory-based study.Frontiers in psychology · 2026Article
- Loneliness and all-cause mortality in the United States.PloS one · 2026Article
- Factors influencing older adults' intention to use social chatbots: examining technology acceptance, anthropomorphism, authenticity, and artificial intelligence social interaction.Innovation in aging · 2026Article
- Mysterious cohabitation with socially assistive robots among three underserved groups.Innovation in aging · 2026Article
- Effects of social isolation on all-cause mortality in older adults: do age, gender, and measurement matter?Innovation in aging · 2026Article
- Impact of the rollout of the national social prescribing link worker programme on population outcomes: evidence from a repeated cross-sectional survey.The British journal of general practice : the journal of the Royal College of General Practitioners · 2025Article
- Social integration and mortality across the life course: findings from the Tromsø study.BMC public health · 2025Article
- Pharmacological interventions to enhance exercise capacity in patients with heart failure.World journal of cardiology · 2025Review
- Social factors, health policy, and environment: implications for cardiovascular disease across the globe.European heart journal · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough several epidemiological studies have linked social isolation to increased risk of mortality, the magnitude of any effect is unclear, in part because of the use of different measures of social isolation.
objectiveTo examine the association between social isolation and all-cause mortality and investigate whether it differs in various subgroups or populations. DATA SOURCES: We searched for relevant studies in electronic databases: MEDLINE (1946 to December 31, 2021), EMBASE (1974 to December 31, 2021), and PsycINFO (1806 to December 31, 2021). SELECTION CRITERIA: We included both prospective and retrospective cohort studies that examined the association between social isolation and all-cause mortality among adults. DATA COLLECTION AND ANALYSIS: Two reviewers screened and extracted data independently. We contacted study authors to obtain missing information whenever possible. Data were pooled using a random effect model to calculate estimates of the effects of social isolation on all-cause mortality.
resultsData from studies involving 1.30 million individuals were included. The pooled hazard ratio of social isolation for all-cause mortality was 1.33 (95% confidence interval; 1.26-1.41, heterogeneity: Chi² = 112.51, P < 0.00001, I² = 76%).
conclusionSocial isolation is associated with increased risk for all-cause mortality. REGISTRATION: PROSPERO (CRD42020152351).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.