Evidence map›Paper›PMID 36634134›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

STING controls T cell memory fitness during infection through T cell-intrinsic and IDO-dependent mechanisms.

Michael J Quaney, Curtis J Pritzl, Dezzarae Luera, Rebecca J Newth, Karin M Knudson, Vikas Saxena, Caitlyn Guldenpfennig, Diana Gil, Chris S Rae, Peter Lauer and 2 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. The STING signaling pathways and bacterial infection.Apoptosis : an international journal on programmed cell death · 2025
    Review
  9. The High-Affinity IL-2 Receptor Affects White Matter Damage after Cerebral Ischemia by Regulating CD8 + T Lymphocyte Differentiation.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2025
    Article
  10. Review
  11. Gene Expression Dysregulation in Whole Blood of Patients withInternational journal of molecular sciences · 2024
    Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. NFκB signaling in T cell memory.Frontiers in immunology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Michael J QuaneyDepartment of Molecular Microbiology and Immunology, School of Medicine, University of Missouri, Columbia 65212, MO.
Curtis J PritzlDepartment of Molecular Microbiology and Immunology, School of Medicine, University of Missouri, Columbia 65212, MO.ORCID 0000-0001-5238-5086
Dezzarae LueraDepartment of Molecular Microbiology and Immunology, School of Medicine, University of Missouri, Columbia 65212, MO.ORCID 0000-0001-5353-7694
Rebecca J NewthDepartment of Molecular Microbiology and Immunology, School of Medicine, University of Missouri, Columbia 65212, MO.
Karin M KnudsonDepartment of Molecular Microbiology and Immunology, School of Medicine, University of Missouri, Columbia 65212, MO.
Vikas SaxenaDepartment of Molecular Microbiology and Immunology, School of Medicine, University of Missouri, Columbia 65212, MO.ORCID 0000-0003-4816-4875
Caitlyn GuldenpfennigDepartment of Molecular Microbiology and Immunology, School of Medicine, University of Missouri, Columbia 65212, MO.ORCID 0000-0002-9633-0869
Diana GilRoy Blunt NextGen Precision Health Building, School of Medicine, University of Missouri, Columbia 65211, MO.ORCID 0000-0003-1744-3484
Chris S RaeNutcracker Therapeutics, Inc., Emeryville 94608, CA.
Peter LauerAduro Biotech, Inc., Berkeley 94704, CA.ORCID 0000-0001-9984-1392
Mark A DanielsDepartment of Molecular Microbiology and Immunology, School of Medicine, University of Missouri, Columbia 65212, MO.ORCID 0000-0002-5175-9901
Emma TeixeiroDepartment of Molecular Microbiology and Immunology, School of Medicine, University of Missouri, Columbia 65212, MO.
University of Missouri · USAduro BioTech (United States) · US

Funding

Human CD3epsilon co-potentiation to boost immunotherapyU01CA244314 · NCI · UNIVERSITY OF MISSOURI-COLUMBIA · PI GIL PAGES, DIANA · 2019 to 2024
$3.8M
IMSD: An Initiative to Maximize Student Development in Biomedical Research at MUT32GM135744 · NIGMS · UNIVERSITY OF MISSOURI-COLUMBIA · PI SCHRUM, ADAM G. · 2020 to 2025
$2.6M
TCR signal transduction in the regulation of T cell memoryR01AI110420 · NIAID · UNIVERSITY OF MISSOURI-COLUMBIA · PI TEIXEIRO, EMMA · 2015 to 2019
$1.8M
T cell signal transduction in the regulation of T cell memory in response to infectionR56AI110420 · NIAID · UNIVERSITY OF MISSOURI-COLUMBIA · PI TEIXEIRO, EMMA · 2021 to 2021
$260k
NCI NIH HHS U01 CA244314NIAID NIH HHS R01 AI110420NIAID NIH HHS R56 AI110420NIGMS NIH HHS T32 GM135744
6 · The paper itself

Abstract

Stimulator of interferon genes (STING) signaling has been extensively studied in inflammatory diseases and cancer, while its role in T cell responses to infection is unclear. Using

Indexed as

Receptors, Antigen, T-CellSignal TransductionCD8-Positive T-LymphocytesIndoleamine-Pyrrole 2,3,-DioxygenaseMemory T CellsIndoleamine-Pyrrole 2,3,-DioxygenaseReceptors, Antigen, T-CellCD8 T cell memorySTINGTCR

Identifiers

PMID36634134
PMCPMC9934307
OpenAlexW4315709065

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.