Evidence map›Paper›PMID 36634100›Full record

ArticleACS biomaterials science & engineering2023

Electromechanical Cornea Reshaping for Refractive Vision Therapy.

Anna M Stokolosa, Jack Thomas-Colwell, Katelyn K Dilley, Yueqiao Qu, Charlotte Cullip, Andrew E Heidari, Michelle Huang, Nathalie Kerrigan, Kellie Hsu, Jack Leonard and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS biomaterials science & engineering, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Anna M StokolosaDepartment of Chemistry, Occidental College, Los Angeles, California 90041, United States.
Jack Thomas-ColwellDepartment of Chemistry, Occidental College, Los Angeles, California 90041, United States.
Katelyn K DilleyBeckman Laser Institute & Medical Clinic, University of California, Irvine, Irvine, California 92697, United States.ORCID 0000-0002-3034-5662
Yueqiao QuBeckman Laser Institute & Medical Clinic, University of California, Irvine, Irvine, California 92697, United States.
Charlotte CullipDepartment of Chemistry, Occidental College, Los Angeles, California 90041, United States.
Andrew E HeidariBeckman Laser Institute & Medical Clinic, University of California, Irvine, Irvine, California 92697, United States.
Michelle HuangDepartment of Chemistry, Occidental College, Los Angeles, California 90041, United States.ORCID 0000-0003-4756-5247
Nathalie KerriganDepartment of Chemistry, Occidental College, Los Angeles, California 90041, United States.
Kellie HsuDepartment of Chemistry, Occidental College, Los Angeles, California 90041, United States.
Jack LeonardDepartment of Chemistry, Occidental College, Los Angeles, California 90041, United States.ORCID 0000-0003-0910-7659
Karthik R Prasad
Brian J F WongBeckman Laser Institute & Medical Clinic, University of California, Irvine, Irvine, California 92697, United States.
Michael G HillDepartment of Chemistry, Occidental College, Los Angeles, California 90041, United States.ORCID 0000-0002-9085-7141
Occidental College · USUniversity of California, Irvine · US

Funding

Acquisition of nonlinear optical microscopy platform for advanced tissue imagingS10OD028698 · OD · UNIVERSITY OF CALIFORNIA-IRVINE · PI POTMA, ERIC OLAF · 2020 to 2020
$1.6M
The Electromechanical Reshaping of CorneaR15EY032273 · NEI · OCCIDENTAL COLLEGE · PI MICHAEL G HILL · 2021 to 2026
$679k
NEI NIH HHS R15 EY032273NIH HHS S10 OD028698
6 · The paper itself

Abstract

The corneal stroma consists of orthogonally stacked collagen-fibril lamellae that determine the shape of the cornea and provide most of the refractive power of the eye. We have applied electromechanical reshaping (EMR), an electrochemical platform for remodeling cartilage and other semirigid tissues, to change the curvature of the cornea as a potential procedure for nonsurgical vision correction. EMR relies on short electrochemical pulses to electrolyze water, with subsequent diffusion of protons into the extracellular matrix of collagenous tissues; protonation of immobilized anions within this matrix disrupts the ionic-bonding network, leaving the tissue transiently responsive to mechanical remodeling. Re-equilibration to physiological pH restores the ionic matrix, resulting in persistent shape change of the tissue. Using

Indexed as

CorneaCorneal StromaAnimalsCollagenExtracellular MatrixRabbitsTomography, Optical CoherenceCollagencorneaelectrochemistryoptical coherence tomography (OCT)stress-relaxationvision refraction

Identifiers

PMID36634100
PMCPMC9930080
OpenAlexW4315708896

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.