Evidence map›Paper›PMID 36633863›Full record

ReviewJournal of applied physiology (Bethesda, Md. : 1985)2023

Lactate as a myokine and exerkine: drivers and signals of physiology and metabolism.

George A Brooks, Adam D Osmond, Jose A Arevalo, Justin J Duong, Casey C Curl, Diana D Moreno-Santillan, Robert G Leija

Registry-linked trialOpen access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of applied physiology (Bethesda, Md. : 1985), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06791837 (Cerebral Lactate Uptake and Transport in Obese and Non-Obese Individuals), which is not on this map. Cited by 96 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
96citing papers in PubMed, 3 pooled it
22.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06791837 recruitingnot on this mapstarted 2025, after this paper: background citation

Cerebral Lactate Uptake and Transport in Obese and Non-Obese Individuals

TypeobservationalSponsorUniversity of Missouri-ColumbiaRan2025 to 2027Enrolled24ConditionsDiabetes, ObesityArmsEXERCISE
3 · Its place in the literature

Who cites it

96 citing papers in PubMed, 3 syntheses or guidelines pooled it, 129 citations in OpenAlex.

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36 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

George A BrooksExercise Physiology Laboratory, Department of Integrative Biology, University of California, Berkeley, California, United States.ORCID 0000-0002-1389-1629
Adam D OsmondExercise Physiology Laboratory, Department of Integrative Biology, University of California, Berkeley, California, United States.
Jose A ArevaloExercise Physiology Laboratory, Department of Integrative Biology, University of California, Berkeley, California, United States.
Justin J DuongExercise Physiology Laboratory, Department of Integrative Biology, University of California, Berkeley, California, United States.
Casey C CurlExercise Physiology Laboratory, Department of Integrative Biology, University of California, Berkeley, California, United States.
Diana D Moreno-SantillanExercise Physiology Laboratory, Department of Integrative Biology, University of California, Berkeley, California, United States.
Robert G LeijaExercise Physiology Laboratory, Department of Integrative Biology, University of California, Berkeley, California, United States.ORCID 0000-0002-7862-293X
University of California, Berkeley · US

Funding

Aging Mitochondrial Fragmentation and Metabolic InflexibilityR01AG059715 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI BROOKS, GEORGE AUSTIN · 2018 to 2022
$3.0M
NIA NIH HHS R01 AG059715
6 · The paper itself

Abstract

No longer viewed as a metabolic waste product and cause of muscle fatigue, a contemporary view incorporates the roles of lactate in metabolism, sensing and signaling in normal as well as pathophysiological conditions. Lactate exists in millimolar concentrations in muscle, blood, and other tissues and can rise more than an order of magnitude as the result of increased production and clearance limitations. Lactate exerts its powerful driver-like influence by mass action, redox change, allosteric binding, and other mechanisms described in this article. Depending on the condition, such as during rest and exercise, following carbohydrate nutrition, injury, or pathology, lactate can serve as a myokine or exerkine with autocrine-, paracrine-, and endocrine-like functions that have important basic and translational implications. For instance, lactate signaling is: involved in reproductive biology, fueling the heart, muscle adaptation, and brain executive function, growth and development, and a treatment for inflammatory conditions. Lactate also works with many other mechanisms and factors in controlling cardiac output and pulmonary ventilation during exercise. Ironically, lactate can be disruptive of normal processes such as insulin secretion when insertion of lactate transporters into pancreatic β-cell membranes is not suppressed, and in carcinogenesis when factors that suppress carcinogenesis are inhibited, whereas factors that promote carcinogenesis are upregulated. Lactate signaling is important in areas of intermediary metabolism, redox biology, mitochondrial biogenesis, neurobiology, gut physiology, appetite regulation, nutrition, and overall health and vigor. The various roles of lactate as a myokine and exerkine are reviewed.

Indexed as

Lactic AcidMusclesCarcinogenesisExerciseHumansOxidation-ReductionLactic Acidcardiopulmonary regulationglucose paradoxlactate shuttlelactylationmetabolic signaling

Identifiers

PMID36633863
PMCPMC9970662
OpenAlexW4315754627

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.