Evidence map›Paper›PMID 36633808›Full record

ArticleAnalytical sciences : the international journal of the Japan Society for Analytical Chemistry2023

Optimization of HPLC-MS/MS method for determination of antimalarial adulterants in herbal products.

Christopher J Mwankuna, Feven Kiros, Eliapenda E Mariki, Faith P Mabiki, Hamisi M Malebo, Robinson H Mdegela, Bjarne Styrishave

Abstract read
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In one paragraph

Article in Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Anti-tumor mechanism of artesunate.Frontiers in pharmacology · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Christopher J MwankunaDepartment of Chemistry and Physics, College of Natural and Applied Sciences, Sokoine University of Agriculture, P.O. Box 3038, Morogoro, Tanzania. cmwankuna@sua.ac.tz.ORCID http://orcid.org/0000-0002-6887-6805
Feven KirosToxicology Laboratory, Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark Universitetsparken 2, DK-2100, Copenhagen, Denmark.
Eliapenda E MarikiDepartment of Chemistry and Physics, College of Natural and Applied Sciences, Sokoine University of Agriculture, P.O. Box 3038, Morogoro, Tanzania.
Faith P MabikiDepartment of Chemistry and Physics, College of Natural and Applied Sciences, Sokoine University of Agriculture, P.O. Box 3038, Morogoro, Tanzania.
Hamisi M MaleboUNESCO National Commission of the United Republic of Tanzania, 7 Magogoni Street, P.O. Box 20384, Dar Es Salaam, Tanzania.
Robinson H MdegelaDepartment of Veterinary Medicine and Public Health, College of Veterinary Medicine and Biomedical Sciences, Sokoine University of Agriculture, P.O. Box 3015, Morogoro, Tanzania.
Bjarne StyrishaveToxicology Laboratory, Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark Universitetsparken 2, DK-2100, Copenhagen, Denmark.

Funding

Danida Fellowship Centre 18-03-TAN
6 · The paper itself

Abstract

The use of herbal products is booming all over the world because of being believed as safer than conventional drugs and free of side effects. However, there are untrustworthy manufacturers who adulterate herbal products by adding conventional drugs which might eventually lead to microbial resistance and herb-to-drug interactions. There is a need to develop methods for detecting adulterants in herbal products. A high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method for simultaneous identification and determination of conventional antimalarials (chloroquine, quinine, sulfadoxine, pyrimethamine, mefloquine, lumefantrine, amodiaquine, artemisinin, dihydroartemisinin, artesunate and artemether) in herbal products was developed. Stable isotopically labelled compounds (artemether-d

Indexed as

AntimalarialsAmodiaquineArtemetherArtemisininsChromatography, High Pressure LiquidFormatesLumefantrineMefloquineMethanolPyrimethamineSulfadoxineTandem Mass SpectrometryAmodiaquineAntimalarialsArtemetherArtemisininsartenimolFormatesformic acidLumefantrineMefloquineMethanolPyrimethamineSulfadoxineAdulterationConventional drugsHerbal drugsHerbal products

Identifiers

PMID36633808

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.