Evidence map›Paper›PMID 36633738›Full record

SynthesisBrain imaging and behavior2023

Meta-analytic connectivity modelling of functional magnetic resonance imaging studies in autism spectrum disorders.

Alicia M Goodwill, Li Tong Low, Peter T Fox, P Mickle Fox, Kenneth K Poon, Sourav S Bhowmick, S H Annabel Chen

Full text readMeta-AnalysisReview
In one paragraph

Synthesis in Brain imaging and behavior, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alicia M GoodwillPhysical Education and Sports Science Academic Group, National Institute of Education, Nanyang Technological University, Singapore, Singapore. alicia.goodwill@nie.edu.sg.ORCID http://orcid.org/0000-0003-2549-7327
Li Tong LowCentre for Research and Development in Learning, Nanyang Technological University, Singapore, Singapore.
Peter T FoxResearch Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
P Mickle FoxResearch Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Kenneth K PoonOffice of Education Research, National Institute of Education, Nanyang Technological University, Singapore, Singapore.
Sourav S BhowmickSchool of Computer Science and Engineering, Nanyang Technological University, Singapore, Singapore.
S H Annabel ChenCentre for Research and Development in Learning, Nanyang Technological University, Singapore, Singapore. annabelchen@ntu.edu.sg.

Funding

Meta-anaylsis in human brain mappingR01MH074457 · NIMH · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FOX, PETER THORNTON · 2006 to 2024
$10.5M
Ministry of Education Singapore, Academic Research Fund RT09/19NIMH NIH HHS R01 MH074457
6 · The paper itself

Abstract

Social and non-social deficits in autism spectrum disorders (ASD) persist into adulthood and may share common regions of aberrant neural activations. The current meta-analysis investigated activation differences between ASD and neurotypical controls irrespective of task type. Activation likelihood estimation meta-analyses were performed to examine consistent hypo-activated and/or hyper-activated regions for all tasks combined, and for social and non-social tasks separately; meta-analytic connectivity modelling and behavioral/paradigm analyses were performed to examine co-activated regions and associated behaviors. One hundred studies (mean age range = 18-41 years) were included. For all tasks combined, the ASD group showed significant (p < .05) hypo-activation in one cluster around the left amygdala (peak - 26, -2, -20, volume = 1336 mm

Indexed as

Autism Spectrum DisorderAdolescentAdultBrainBrain MappingCerebellumHumansLanguageMagnetic Resonance ImagingSemanticsYoung AdultAdultAutism spectrum disorderBrainMapfMRIMeta-analysisMeta-analytic connectivity modelling

Identifiers

PMID36633738
PMCPMC10049951

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read11
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.