Evidence map›Paper›PMID 36633702›Full record

ArticleEJNMMI research2023

Development of a minimally invasive simultaneous estimation method for quantifying translocator protein binding with [

Praveen Dassanayake, Udunna C Anazodo, Linshan Liu, Lucas Narciso, Maryssa Iacobelli, Justin Hicks, Pablo Rusjan, Elizabeth Finger, Keith St Lawrence

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EJNMMI research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Evaluating image-derived input functions for cerebral [Frontiers in nuclear medicine · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Praveen DassanayakeDepartment of Medical Biophysics, University of Western Ontario, London, ON, Canada. pdassana@uwo.ca.ORCID http://orcid.org/0000-0002-5989-4921
Udunna C AnazodoDepartment of Medical Biophysics, University of Western Ontario, London, ON, Canada.
Linshan LiuLawson Health Research Institute, 268 Grosvenor St, London, ON, N6A 4V2, Canada.
Lucas NarcisoDepartment of Medical Biophysics, University of Western Ontario, London, ON, Canada.
Maryssa IacobelliLawson Health Research Institute, 268 Grosvenor St, London, ON, N6A 4V2, Canada.
Justin HicksDepartment of Medical Biophysics, University of Western Ontario, London, ON, Canada.
Pablo RusjanDouglas Research Centre, Human Neuroscience Division, Montréal, QC, Canada.
Elizabeth FingerLawson Health Research Institute, 268 Grosvenor St, London, ON, N6A 4V2, Canada.
Keith St LawrenceDepartment of Medical Biophysics, University of Western Ontario, London, ON, Canada.

Funding

Alzheimer Society R3592A14
6 · The paper itself

Abstract

backgroundThe purpose of this study was to assess the feasibility of using a minimally invasive simultaneous estimation method (SIME) to quantify the binding of the 18-kDa translocator protein tracer [

resultsSIME was applied to retrospective data from healthy volunteers and was comprised of both high-affinity binders (HABs) and mixed-affinity binders (MABs). Estimates of global V

conclusionsThe results of this study demonstrate that accurate estimates of regional V

Indexed as

Image-derived input functionKinetic modelingPET/MRPositron emission tomographySimultaneous estimation methodTranslocator protein (TSPO) imaging

Identifiers

PMID36633702
PMCPMC9837356

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.