Evidence map›Paper›PMID 36633664›Full record

ArticleJournal of gastroenterology2023

Treatment strategy after noncurative endoscopic resection for early gastric cancers in patients aged ≥ 85 years: a multicenter retrospective study in a highly aged area of Japan.

Waku Hatta, Yosuke Toya, Tomohiro Shimada, Koichi Hamada, Ko Watanabe, Jun Nakamura, Daisuke Fukushi, Tomoyuki Koike, Hirohiko Shinkai, Hirotaka Ito and 32 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Journal of gastroenterology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Competing Mortality Redefines the Net Benefit of Additional Surgery After Endoscopic Resection for T1 Colorectal Cancer in Older Adults.Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society · 2026
    Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

42 authors at 20 institutions in 1 country.

Waku HattaDivision of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-Machi, Aoba-Ku, Sendai, Miyagi, 980-8574, Japan. waku-style@festa.ocn.ne.jp.ORCID 0000-0001-9717-0281
Yosuke Toya *Division of Gastroenterology, Department of Internal Medicine, School of Medicine, Iwate Medical University, Yahaba, Japan.
Tomohiro ShimadaDepartment of Gastroenterology, Sendai City Medical Center, Sendai, Japan.
Koichi HamadaDepartment of Minimally Invasive Surgical and Medical Oncology, Fukushima Medical University, Fukushima, Japan.
Ko WatanabeDepartment of Gastroenterology, Ohara General Hospital, Fukushima, Japan.
Jun NakamuraDepartment of Endoscopy, Fukushima Medical University Hospital, Fukushima, Japan.
Daisuke FukushiDivision of Gastroenterology Tohoku Medical and Pharmaceutical University, Sendai, Japan.
Tomoyuki KoikeDivision of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-Machi, Aoba-Ku, Sendai, Miyagi, 980-8574, Japan.
Hirohiko ShinkaiDepartment of Gastroenterology, Iwate Prefectural Isawa Hospital, Oshu, Japan.
Hirotaka ItoDepartment of Gastroenterology, Osaki Citizen Hospital, Osaki, Japan.
Tamotsu MatsuhashiDepartment of Gastroenterology and Neurology, Akita University Graduate School of Medicine, Akita, Japan.
Shusei FujimoriDepartment of Gastroenterology, Yokote Municipal Hospital, Yokote, Japan.
Wataru IwaiDepartment of Gastroenterology, Miyagi Cancer Center, Natori, Japan.
Norihiro HanabataDivision of Endoscopy, Aomori Prefectural Central Hospital, Aomori, Japan.
Takeharu ShirokiDepartment of Gastroenterology, Iwate Prefectural Central Hospital, Morioka, Japan.
Yu SasakiDepartment of Gastroenterology, Faculty of Medicine, Yamagata University, Yamagata, Japan.
Yuukou FujishimaDivision of Gastroenterology, Noshiro Kosei Medical Center, Noshiro, Japan.
Tsuyotoshi TsujiDepartment of Gastroenterology, Akita City Hospital, Akita, Japan.
Haruka YorozuDigestive Disease Center, Akita Red Cross Hospital, Akita, Japan.
Tetsuro YoshimuraDivision of Gastroenterology, Aomori City Hospital, Aomori, Japan.
Yohei HorikawaDepartment of Gastroenterology, Hiraka General Hospital, Yokote, Japan.
Yasushi TakahashiDepartment of Gastroenterology, National Hospital Organization Sendai Medical Center, Sendai, Japan.
Hiroshi TakahashiDepartment of Gastroenterology, Iwate Prefectural Ninohe Hospital, Ninohe, Japan.
Yutaka KondoDivision of Gastroenterology, Tohoku Rosai Hospital, Sendai, Japan.
Takao FujiwaraDepartment of Gastroenterology, Japanese Red Cross Morioka Hospital, Morioka, Japan.
Hisata MizugaiDepartment of Gastroenterology, Hachinohe Red Cross Hospital, Hachinohe, Japan.
Takahiro GonaiDepartment of Gastroenterology, Iwate Prefectural Kuji Hospital, Kuji, Japan.
Tetsuya TatsutaDepartment of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Kengo OnochiDepartment of Gastroenterology, Omagari Kosei Medical Center, Daisen, Japan.
Norihiko KudaraDepartment of Internal Medicine and Gastroenterology, Iwate Prefectural Ofunato Hospital, Ofunato, Japan.
Keinosuke AbeDepartment of Gastroenterology, Iwate Prefectural Miyako Hospital, Miyako, Japan.
Yohei OgataDivision of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-Machi, Aoba-Ku, Sendai, Miyagi, 980-8574, Japan.
Tetsuya OhiraDepartment of Gastroenterology, Sendai City Medical Center, Sendai, Japan.
Yoshinori HorikawaDepartment of Gastroenterology, Southern-Tohoku General Hospital, Fukushima, Japan.
Ryoichi IshihataDepartment of Gastroenterology, Ohara General Hospital, Fukushima, Japan.
Takuto HikichiDepartment of Endoscopy, Fukushima Medical University Hospital, Fukushima, Japan.
Kennichi SatohDivision of Gastroenterology Tohoku Medical and Pharmaceutical University, Sendai, Japan.
Katsunori IijimaDepartment of Gastroenterology and Neurology, Akita University Graduate School of Medicine, Akita, Japan.
Shinsaku FukudaDepartment of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Takayuki MatsumotoDivision of Gastroenterology, Department of Internal Medicine, School of Medicine, Iwate Medical University, Yahaba, Japan.
Atsushi MasamuneDivision of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-Machi, Aoba-Ku, Sendai, Miyagi, 980-8574, Japan.
for Tohoku GI Endoscopy Group
Iwate Prefectural Central Hospital · JPTohoku University · JPSendai Medical Center · JPAkita University · JPFukushima Medical University Hospital · JPHiraka General Hospital · JPHirosaki University · JPIwate Medical University · JPSeirei Hamamatsu General Hospital · JPTohoku Medical and Pharmaceutical University · JPAkita Red Cross Hospital · JPAkita University Hospital · JPAomori Prefectural Central Hospital · JPAomori Rosai Hospital · JPFukushima Medical University · JPJapanese Red Cross Hadano Hospital · JPMiyagi Prefectural Hospital Organization · JPNagaoka Red Cross Hospital · JPOsaki Citizen Hospital · JPTohoku Rosai Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe guidelines recommend additional gastrectomy after noncurative endoscopic resection for early gastric cancers (EGCs). However, no additional treatment might be acceptable in some patients aged ≥ 85 years. We aimed to identify this patient group using the data in a highly aged area.

methodsWe enrolled patients aged ≥ 85 years after noncurative endoscopic resection for EGCs at 30 institutions of the Tohoku district in Japan between 2002 and 2017. Treatment selection and prognosis after noncurative endoscopic resection were investigated. Fourteen candidates were evaluated using the Cox model to identify risk factors for poor overall survival (OS) in patients with no additional treatment.

resultsOf 1065 patients aged ≥ 85 years, 143 underwent noncurative endoscopic resection. Despite the guidelines' recommendation, 88.8% of them underwent no additional treatment. The 5-year OS rates in those with additional gastrectomy and those with no additional treatment were 63.1 and 65.2%, respectively. Multivariate analysis showed independent risk factors for poor OS in patients with no additional treatment were the high-risk category in the eCura system (hazard ratio [HR], 2.91), Charlson comorbidity index (CCI) ≥ 3 (HR, 2.78), and male (HR, 2.04). In patients with no additional treatment, nongastric cancer-specific survival was low (69.0% in 5 years), whereas disease-specific survival rates were very high in the low- and intermediate-risk categories of the eCura system (100.0 and 97.1%, respectively, in 5 years).

conclusionsNo additional treatment may be acceptable in the low- and intermediate-risk categories of the eCura system in patients aged ≥ 85 years with noncurative endoscopic resection for EGCs.

Indexed as

Endoscopic Mucosal ResectionStomach NeoplasmsGastrectomyGastric MucosaHumansJapanMaleRetrospective StudiesTreatment OutcomeEarly gastric cancerseCura systemNoncurative endoscopic resectionPatients aged ≥ 85 years

Identifiers

PMID36633664
OpenAlexW4315705412

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.