Evidence map›Paper›PMID 36633452›Full record

SynthesisDeutsches Arzteblatt international2023

Post-COVID Syndrome.

Michael Hallek, Kristina Adorjan, Uta Behrends, Georg Ertl, Norbert Suttorp, Clara Lehmann

Open access · greenAbstract readSystematic Review
In one paragraph

Synthesis in Deutsches Arzteblatt international, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
13.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.

  1. Definitions and symptoms of the post-COVID syndrome: an updated systematic umbrella review.European archives of psychiatry and clinical neuroscience · 2025
    Pooled it
  2. Article
  3. Impact of nutrition on long COVID.Sports medicine and health science · 2026
    Review
  4. Article
  5. Article
  6. Observational
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Observational
  14. Review
  15. Article
  16. Observational
  17. Headache severity in patients with post COVID-19 condition: a case-control study.European archives of psychiatry and clinical neuroscience · 2024
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Michael HallekDepartment I of Internal Medicine, Center of Integrated Oncology ABCD, University Hospital of Cologne and German Medical Association, Berlin; Department of Psychiatry and Psychotherapy, LMU University Hospital, Munich; Munich Chronic Fatigue Center for Young People, Children's Hospital, School of Medicine, Technical University Munich; German Society of Internal Medicine e.V. and Comprehensive Heart Failure Center, Würzburg; Medical Department of Infectious Diseases and Respiratory Medicine CCM/CVK/CBF, Charité-Universitätsmedizin Berlin; Department I of Internal Medicine, Division of Infectious Diseases, Faculty of Medicine and University Hospital Cologne, University of Cologne.
Kristina Adorjan
Uta Behrends
Georg Ertl
Norbert Suttorp
Clara Lehmannon behalf of the Long COVID Working Group of the Scientific Advisory Board within the German Medical Association.
Advisory Board Company (United States) · USDeutsches Herzzentrum München · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAs defined by the WHO, the term post-COVID syndrome (PCS) embraces a group of symptoms that can occur following the acute phase of a SARS-CoV-2 infection and as a consequence thereof. PCS is found mainly in adults, less frequently in children and adolescents. It can develop both in patients who initially had only mild symptoms or none at all and in those who had a severe course of coronavirus disease 2019 (COVID-19).

methodsThe data presented here were derived from a systematic literature review.

resultsPCS occurs in up to 15% of unvaccinated adults infected with SARS-CoV-2. The prevalence has decreased in the most recent phase of the pandemic and is lower after vaccination. The pathogenesis of PCS has not yet been fully elucidated. Virustriggered inflammation, autoimmunity, endothelial damage (to blood vessels), and persistence of virus are thought to be causative. Owing to the broad viral tropism, different organs are involved and the symptoms vary. To date, there are hardly any evidence-based recommendations for definitive diagnosis of PCS or its treatment.

conclusionThe gaps in our knowledge mean that better documentation of the prevalence of PCS is necessary to compile the data on which early detection, diagnosis, and treatment can be based. To ensure the best possible care of patients with PCS, regional PCS centers and networks embracing existing structures from all healthcare system sectors and providers should be set up and structured diagnosis and treatment algorithms should be established. Given the sometimes serious consequences of PCS for those affected, it seems advisable to keep the number of SARS-CoV-2 infections low by protective measures tailored to the prevailing pandemic situation.

Indexed as

COVID-19AdolescentAdultChildHumansInflammationPandemicsSARS-CoV-2Vaccination

Identifiers

PMID36633452
PMCPMC10060997
OpenAlexW4315752654

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.