Evidence map›Paper›PMID 36633407›Full record

ArticleJournal of virology2023

Identification of B-Cell Epitopes on Capsid Protein Reveals Two Potential Neutralization Mechanisms in Red-Spotted Grouper Nervous Necrosis Virus.

Zhiqi Zhang, Jing Xing, Xiaoqian Tang, Xiuzhen Sheng, Heng Chi, Wenbin Zhan

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Zhiqi ZhangLaboratory of Pathology and Immunology of Aquatic Animals, KLMME, Ocean University of China, Qingdao, China.
Jing XingLaboratory of Pathology and Immunology of Aquatic Animals, KLMME, Ocean University of China, Qingdao, China.ORCID 0000-0003-0096-3061
Xiaoqian TangLaboratory of Pathology and Immunology of Aquatic Animals, KLMME, Ocean University of China, Qingdao, China.
Xiuzhen ShengLaboratory of Pathology and Immunology of Aquatic Animals, KLMME, Ocean University of China, Qingdao, China.
Heng ChiLaboratory of Pathology and Immunology of Aquatic Animals, KLMME, Ocean University of China, Qingdao, China.
Wenbin ZhanLaboratory of Pathology and Immunology of Aquatic Animals, KLMME, Ocean University of China, Qingdao, China.ORCID 0000-0002-5672-5137
Ocean University of China · CNQingdao National Laboratory for Marine Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nervous necrosis virus (NNV), a formidable pathogen in marine and freshwater fish, has inflicted enormous financial tolls on the aquaculture industry worldwide. Although capsid protein (CP) is the sole structural protein with pathogenicity and antigenicity, public information on immunodominant regions remains extremely scarce. Here, we employed neutralizing monoclonal antibodies (MAbs) specific for red-spotted grouper NNV (RGNNV) CNPgg2018 in combination with partially overlapping truncated proteins and peptides to identify two minimal B-cell epitope clusters on CP,

Indexed as

BassFish DiseasesNodaviridaeRNA Virus InfectionsAnimalsCapsid ProteinsEpitopes, B-LymphocyteImmunodominant EpitopesNecrosisCapsid ProteinsEpitopes, B-LymphocyteImmunodominant Epitopescapsid proteinimmunoinformaticnervous necrosis virusneutralization mechanismneutralizing B-cell epitope

Identifiers

PMID36633407
PMCPMC9888288
OpenAlexW4315754194

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.